Basic Information
| Drug ID | DDPD01182 |
|
| Drug Name | Propafenone | |
| Molecular Weight | 341.444 | |
| Molecular Formula | C21H27NO3 | |
| CAS Number | 54063-53-5 | |
| SMILES | CCCNCC(O)COC1=C(C=CC=C1)C(=O)CCC1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB01182 | |
| PubChem Compound | 4932 | |
| PDR | 223 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.2 | - | 3.2 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 90.0 | % | 90 | % | DRUGBANK | |
| Bioavailability | 27.5 | % | 5-50 | % | DRUGBANK | Bioavailability | 3.4 | % | 3.4 | % | Tablet, PO, oral; | DRUGBANK | Bioavailability | 10.6 | % | 10.6 | % | Tablet, PO, oral; | DRUGBANK |
| Clearance | 0.96 | L/h/kg | 16 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 252.0 | L | 252.0 | L | DRUGBANK | Volume of Distribution | 2.2 | L/kg | 2.2 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 6.0 | h | 2-10 | h | DRUGBANK | Half-life | 2.1 | h | 2.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 97.0 | % | 97 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 600.0 | mg/m2/day | 600 | mg/m2/day | Tablet,PO，oral | Rythmol | propafenone hydrochloride | PDR |
| Max dose for children | 600.0 | mg/m2/day | 600 | mg/m2/day | Tablet,PO，oral | Rythmol | propafenone hydrochloride | PDR |
| Max dose for adults | 900.0 | mg/day | 900 | mg/day | Tablet,PO，oral | Rythmol | propafenone hydrochloride | PDR |
| Max dose for adults | 850.0 | mg/day | 850 | mg/day | Capsule, PO, Oral | Rythmol | propafenone hydrochloride | PDR |
| Max dose for elderly | 900.0 | mg/day | 900 | mg/day | Tablet,PO，oral | Rythmol | propafenone hydrochloride | PDR |
| Max dose for elderly | 850.0 | mg/day | 850 | mg/day | Capsule, PO, Oral | Rythmol | propafenone hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1