Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01181 ...
Drug Name Ifosfamide
Molecular Weight 261.086
Molecular Formula C7H15Cl2N2O2P
CAS Number 3778-73-2
SMILES ClCCNP1(=O)OCCCN1CCCl
External Links
DRUGBANK DB01181
T3DB T3D3513
PubChem Compound 3690
PDR 2427
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.86 - 0.86 - HANSCH,C ET AL. (1995)
Melting Point 40.0 ℃ 39-41 ℃ U.S. Patent 3,732,340.
Water Solubility 3780.0 mg/L 3780 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 92.0 % 92.0 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 52217200.0 ng/ml 200（163-245） mM PO, oral; Advanced tumors; The Pharmacological Basis of Therapeutics
C Max 53000458.0 ng/ml 203(168-232) mM intravenous injection, IV; Advanced tumors; The Pharmacological Basis of Therapeutics
T Max 0.75 h 0.5-1.0 h PO, oral; Advanced tumors; The Pharmacological Basis of Therapeutics
Clearance 2.4 L/h/m2 2.4±0.33 L/h/m2 pediatric patients; DRUGBANK
Clearance 3.8 L/h/m2 63.0 ml/min/m2 Elderly → ; The Pharmacological Basis of Therapeutics
Clearance 0.37 L/h/m2 6.2±1.9 ml/min/m2 Elderly → ; The Pharmacological Basis of Therapeutics
Clearance 0.0660 L/h/kg 1.1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.64 L/kg 0.64 L/kg Average volume of distribution; intravenous injection, IV; tumor; DRUGBANK
Volume of Distribution 0.72 L/kg 0.72 L/kg Average volume of distribution; intravenous injection, IV; tumor; DRUGBANK
Volume of Distribution 21.0 L/m2 21±1.6 L/m2 Average volume of distribution; pediatric patients; DRUGBANK
Volume of Distribution 12.5 L/m2 12.5±3.6 L/m2 The Pharmacological Basis of Therapeutics
Volume of Distribution 0.62 L/kg 0.62 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 11.0 h 7-15 h Age ↑ ; DRUGBANK
Half-life 5.6 h 5.6 h Male, men;  Female, women; patients; Advanced tumors; intravenous injection, IV; Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 15.2 h 15.2±3.6 h Male, men;  Female, women; patients; Advanced tumors; intravenous injection, IV; Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 6.6 h 6.6 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 697.5 mg/kg 390-1005 mg/kg mouse; DRUGBANK
Toxicity LD50 170.0 mg/kg 150-190 mg/kg Rattus, Rat; DRUGBANK
Toxicity LD50 697.5 mg/kg 390-1005 mg/kg mouse; T3DB
Toxicity LD50 170.0 mg/kg 150-190 mg/kg Rattus, Rat; T3DB
Eliminate Route 78.0 % 70-86 % Urinary excretion; DRUGBANK
Eliminate Route 61.0 % ~61 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 15.0 % 12-18 % Urinary excretion; intravenous injection, IV; Advanced tumors; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 53.1 % 53.1±9.6 % Urinary excretion; intravenous injection, IV; Advanced tumors; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 0 % ~0 % Advanced tumors; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 3000.0 mg/m2 3000 mg/m2 intravenous injection, IV Ifex ifosfamide PDR
Max dose for children 3000.0 mg/m2 3000 mg/m2 intravenous injection, IV Ifex ifosfamide PDR
Max dose for adolescents 1200.0 mg/m2 1200 mg/m2 intravenous injection, IV; 5d/per 21d Ifex ifosfamide PDR
Max dose for adolescents 5000.0 mg/m2 5000 mg/m2 intravenous injection, IV Ifex ifosfamide PDR
Max dose for geriatric 1200.0 mg/m2 1200 mg/m2 intravenous injection, IV Ifex ifosfamide PDR
Max dose for geriatric 5000.0 mg/m2 5000 mg/m2 intravenous injection, IV Ifex ifosfamide PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1