Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01177 ...
Drug Name Idarubicin
Molecular Weight 497.4939
Molecular Formula C26H27NO9
CAS Number 58957-92-9
SMILES C[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)O[C@H]1C[C@@](O)(CC2=C1C(O)=C1C(=O)C3=CC=CC=C3C(=O)C1=C2O)C(C)=O
External Links
DRUGBANK DB01177
PubChem Compound 42890
PDR 1018
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.2 - 0.2 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 28.0 % 28±4 % PO, oral; tumor; The Pharmacological Basis of Therapeutics
C Max 6.9 ng/ml 6.9±0.1 ng/ml Oral single dose; tumor; The Pharmacological Basis of Therapeutics
C Max 22.0 ng/ml 22±4 ng/ml Oral single dose; Active metabolite; tumor; The Pharmacological Basis of Therapeutics
T Max 5.4 h 5.4±2.4 h Oral single dose; tumor; The Pharmacological Basis of Therapeutics
T Max 7.9 h 7.9±2.3 h Oral single dose; Active metabolite; tumor; The Pharmacological Basis of Therapeutics
Clearance 1.7 L/h/kg 29±10 ml/min/kg mild renal function ↓ ;moderate renal function ↓ ; The Pharmacological Basis of Therapeutics
Clearance 1.4 L/h/kg 24 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 24.7 L/kg 24.7±5.9 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 38.0 L/kg 38 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 22.0 h 22 h DRUGBANK
Half-life 15.2 h 15.2±3.7 h The Pharmacological Basis of Therapeutics
Half-life 41.0 h 41±10 h mild renal function ↑ ;moderate renal function ↑ ; The Pharmacological Basis of Therapeutics
Half-life 16.0 h 16 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 5.0 % <5 % Urinary excretion; tumor; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 97.0 % 97 % DRUGBANK
Protein Binding 97.0 % 97 % tumor; human, homo sapiens; The Pharmacological Basis of Therapeutics
Protein Binding 94.0 % 94 % Active metabolite; tumor; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 12.0 mg/m2 12 mg/m2 intravenous injection, IV Idamycin PFS idarubicin hydrochloride PDR
Max dose for adolescents 12.0 mg/m2 12 mg/m2 intravenous injection, IV Idamycin PFS idarubicin hydrochloride PDR
Max dose for adults 12.0 mg/m2 12 mg/m2 intravenous injection, IV Idamycin PFS idarubicin hydrochloride PDR
Max dose for geriatric 12.0 mg/m2 12 mg/m2 intravenous injection, IV Idamycin PFS idarubicin hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1