Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01174 ...
Drug Name Phenobarbital
Molecular Weight 232.2353
Molecular Formula C12H12N2O3
CAS Number 50-06-6
SMILES CCC1(C(=O)NC(=O)NC1=O)C1=CC=CC=C1
External Links
DRUGBANK DB01174
T3DB T3D3006
PubChem Compound 4763
PDR 2669
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.47 - 1.47 - HANSCH,C ET AL. (1995)
Melting Point 174.0 ℃ 174 ℃ PhysProp
Water Solubility 1110.0 mg/L 1110 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
pKa 7.3 - 7.3 - BUDAVARI,S ET AL. (1996)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 100.0 % 100±11 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 13100.0 ng/ml 13.1±4.5 mcg/ml PO, oral; epilepsy; The Pharmacological Basis of Therapeutics
T Max 3.0 h 2-4 h PO, oral; epilepsy; The Pharmacological Basis of Therapeutics
Clearance 0.003720 L/h/kg 0.062±0.013 ml/min/kg Neonates ↑ ;Children ↑ ;Preg, pregnant ↑ ;Somking → ; The Pharmacological Basis of Therapeutics
Clearance 0.003780 L/h/kg 0.063 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.54 L/kg 0.54±0.03 L/kg Neonates ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.54 L/kg 0.54 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 79.0 h 79(53-118) h DRUGBANK
Half-life 99.0 h 99±18 h Children ↓ ;Neonates → ;Hepatic cirrhosis, cirr ↑ ;epilepsy → ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 99.0 h 99 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 24.0 % 24±5 % Urinary excretion; Unchanged drug; Hepatitis, Hep → ;acute viral hepatitis AVH → ; The Pharmacological Basis of Therapeutics
Protein Binding 32.5 % 20-45 % DRUGBANK
Protein Binding 51.0 % 51±3 % Neonates ↓ ;Preg, pregnant → ;Elderly → ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 20.0 mg/kg/dose 20 mg/kg/dose intravenous injection, IV Phenobarbital Elixir phenobarbital PDR
Max dose for neonates 5.0 mg/kg/day 5 mg/kg/day Phenobarbital Elixir phenobarbital PDR
Max dose for infants 20.0 mg/kg/dose 20 mg/kg/dose intravenous injection, IV Phenobarbital Elixir phenobarbital PDR
Max dose for infants 10.0 mg/kg/day 10 mg/kg/day Phenobarbital Elixir phenobarbital PDR
Max dose for children 20.0 mg/kg/dose 20 mg/kg/dose intravenous injection, IV Phenobarbital Elixir phenobarbital PDR
Max dose for children 1000.0 mg/dose 1000 mg/dose intravenous injection, IV Phenobarbital Elixir phenobarbital PDR
Max dose for children 1.0 mg/kg/day 8 mg/kg/day Phenobarbital Elixir phenobarbital PDR
Max dose for children 1.0 mg/kg/day 10 mg/kg/day Phenobarbital Elixir phenobarbital PDR
Max dose for adolescents 20.0 mg/kg/dose 20 mg/kg/dose intravenous injection, IV Phenobarbital Elixir phenobarbital PDR
Max dose for adolescents 1000.0 mg/dose 1000 mg/dose intravenous injection, IV Phenobarbital Elixir phenobarbital PDR
Max dose for adolescents 6.0 mg/kg/day 6 mg/kg/day Phenobarbital Elixir phenobarbital PDR
Max dose for adults 200.0 mg/day 200 mg/day PO, oral Phenobarbital Elixir phenobarbital PDR
Max dose for geriatric 200.0 mg/day 200 mg/day PO, oral Phenobarbital Elixir phenobarbital PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1