Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 10.6 | - | 10.6 | - | DRUGBANK |
| Boiling Point | 377.0 | ℃ | 377 | ℃ | DRUGBANK |
| Melting Point | 132.0 | ℃ | 132 | ℃ | DRUGBANK |
| Water Solubility | 0.000352 | mg/L | 0.000352 | mg/L | DRUGBANK |
| pKa | 10.6 | - | 10.6 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 95.0 | % | >95 | % | PO, oral; | DRUGBANK |
| Bioavailability | 56.0 | % | 56 | % | PO, oral; | DRUGBANK | Bioavailability | 90.0 | % | 90 | % | PO, oral; increasing doses; | DRUGBANK |
| T Max | 0.65 | h | 0.3-1 | h | PO, oral; | DRUGBANK |
| Metabolic | 100.0 | % | ~100 | % | Liver metabolism; | DRUGBANK |
| Clearance | 54.0 | L/h | 30-78 | L/h | Urinary excretion; | DRUGBANK | Clearance | 0.60 | L/h/kg | 10 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.3 | L/kg | 1-1.5 | L/kg | DRUGBANK | Volume of Distribution | 1.1 | L/kg | 1.1 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.5 | h | 1-2 | h | DRUGBANK | Half-life | 4.0 | h | 4 | h | Hepatitis, Hep; | DRUGBANK | Half-life | 1.5 | h | 1.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 730.0 | mg/kg | 730.0 | mg/kg | mouse; | DRUGBANK | Toxicity LD50 | 1300.0 | mg/kg | 1300.0 | mg/kg | Rattus, Rat; | DRUGBANK | Toxicity LD50 | 730.0 | mg/kg | 730.0 | mg/kg | mouse; | T3DB | Toxicity LD50 | 1300.0 | mg/kg | 1300.0 | mg/kg | Rattus, Rat; | T3DB |
| Eliminate Route | 100.0 | % | ~100 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 50.0 | % | ~50 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1