Basic Information
| Drug ID | DDPD01169 |
|
| Drug Name | Arsenic trioxide | |
| Molecular Weight | 197.84 | |
| Molecular Formula | As2O3 | |
| CAS Number | 1327-53-3 | |
| SMILES | O=[As]O[As]=O | |
| External Links | ||
| DRUGBANK | DB01169 | |
| T3DB | T3D0224 | |
| ATSDR | ATSDR Page | |
| PubChem Compound | 261004 | |
| PDR | 2334 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Water Solubility | 17000.0 | mg/L | 17000 | mg/L | SHIU,WY ET AL. 1990) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Toxicity LD50 | 871.0 | mg/kg | 871.0 | mg/kg | Intraperitoneal, IP; Rattus, Rat; | T3DB | Toxicity LD50 | 31.5 | mg/kg | 31 500 | ug/kg | PO, oral; mouse; | T3DB | Toxicity LD50 | 9.8 | mg/kg | 9800.0 | ug/kg | subcutaneous injection, SC; mouse; | T3DB | Toxicity LD50 | 10.7 | mg/kg | 10 700 | ug/kg | intravenous injection, IV; mouse; | T3DB |
| Toxicity Lethal Dose | 200.0 | mg | 200.0 | mg | adults; human, homo sapiens; | T3DB |
| Toxicity MRLs | 0.005000 | mg/kg/day | 0.005 | mg/kg/day | PO, oral; | T3DB | Toxicity MRLs | 0.000300 | mg/kg/day | 0.0003 | mg/kg/day | PO, oral; Oral multiple dose; | T3DB | Toxicity MRLs | 0.000010 | mg/L | 0.01 | mg/m3 | inhalation, IH; Oral multiple dose; | T3DB |
| Protein Binding | 75.0 | % | 75 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for children | 0.15 | mg/kg/day | 0.15 | mg/kg/day | intravenous injection, IV | qd | Trisenox | arsenic trioxide | PDR |
| Max dose for adolescents | 0.15 | mg/kg/day | 0.15 | mg/kg/day | intravenous injection, IV | qd | Trisenox | arsenic trioxide | PDR |
| Max dose for adults | 0.15 | mg/kg/day | 0.15 | mg/kg/day | intravenous injection, IV | qd | Trisenox | arsenic trioxide | PDR |
| Max dose for geriatric | 0.15 | mg/kg/day | 0.15 | mg/kg/day | intravenous injection, IV | qd | Trisenox | arsenic trioxide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1