Basic Information
| Drug ID | DDPD01167 |
|
| Drug Name | Itraconazole | |
| Molecular Weight | 705.633 | |
| Molecular Formula | C35H38Cl2N8O4 | |
| CAS Number | 84625-61-6 | |
| SMILES | CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1 | |
| External Links | ||
| DRUGBANK | DB01167 | |
| T3DB | T3D3516 | |
| PubChem Compound | 55283 | |
| PDR | 1165 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.66 | - | 5.66 | - | HTTP://WWW.RXLIST.COM |
| Melting Point | 166.2 | ℃ | 166.2 | ℃ | DRUGBANK |
| pKa | 3.7 | - | 3.7 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 55.0 | % | 55 | % | DRUGBANK | Bioavailability | 55.0 | % | 55.0 | % | PO, oral; | The Pharmacological Basis of Therapeutics |
| C Max | 649.0 | ng/ml | 649±289 | ng/ml | PO, oral; adults; | The Pharmacological Basis of Therapeutics |
| T Max | 4.0 | h | 3-5 | h | PO, oral; adults; | The Pharmacological Basis of Therapeutics |
| Clearance | 22.9 | L/h | 381±95 | ml/min | intravenous injection, IV; | DRUGBANK | Clearance | 1.4 | L/h/kg | 23±10 | ml/min/kg | apparent clearance; | The Pharmacological Basis of Therapeutics | Clearance | 0.31 | L/h/kg | 5.1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 796.0 | L | 796±185 | L | DRUGBANK | Volume of Distribution | 14.0 | L/kg | 14±5 | L/kg | Apparent volume of distribution; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 7.4 | L/kg | 7.4 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 21.0 | h | 21 | h | DRUGBANK | Half-life | 21.0 | h | 21±6 | h | non-saturable concentration; | The Pharmacological Basis of Therapeutics | Half-life | 64.0 | h | 64 | h | at steady state; | The Pharmacological Basis of Therapeutics | Half-life | 25.0 | h | 25 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 1.0 | % | <1 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 99.8 | % | 99.8 | % | DRUGBANK | Protein Binding | 99.8 | % | 99.8 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 10.0 | mg/kg/day | 10 | mg/kg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for infants | 15.0 | mg/kg/day | 15 | mg/kg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for children | 10.0 | mg/kg/day | 10 | mg/kg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for children | 400.0 | mg/day | 400 | mg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for children | 15.0 | mg/kg/day | 15 | mg/kg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for children | 600.0 | mg/day | 600 | mg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for adolescents | 400.0 | mg/day | 400 | mg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | Tablet,PO，oral;Liquid; | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for adults | 400.0 | mg/day | 400 | mg/day | Capsule, PO, Oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for adults | 260.0 | mg/day | 260 | mg/day | Capsule, PO, Oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for adults | 390.0 | mg/day | 390 | mg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for geriatric | 200.0 | mg/day | 200 | mg/day | Tablet,PO，oral;Liquid; | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for geriatric | 400.0 | mg/day | 400 | mg/day | Capsule, PO, Oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for geriatric | 260.0 | mg/day | 260 | mg/day | Capsule, PO, Oral | Sporanox Oral Solution | itraconazole | PDR |
| Max dose for geriatric | 390.0 | mg/day | 390 | mg/day | PO, oral | Sporanox Oral Solution | itraconazole | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1