Basic Information
| Drug ID | DDPD01165 |
|
| Drug Name | Ofloxacin | |
| Molecular Weight | 361.3675 | |
| Molecular Formula | C18H20FN3O4 | |
| CAS Number | 82419-36-1 | |
| SMILES | CC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1 | |
| External Links | ||
| DRUGBANK | DB01165 | |
| PubChem Compound | 4583 | |
| PDR | 1113 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.39 | - | -0.39 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 254.0 | ℃ | 254 | ℃ | PhysProp |
| Water Solubility | 28300.0 | mg/L | 28.3 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 98.0 | % | 98 | % | DRUGBANK | |
| Clearance | 0.15 | L/h/kg | 2.5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.6 | L/kg | 1.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 9.0 | h | 9 | h | DRUGBANK | Half-life | 8.9 | h | 8.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 5450.0 | mg/kg | 5450.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 6.0 | % | ~4-8 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 72.5 | % | 65-80 | % | Urinary excretion; PO, oral; Unchanged drug; | DRUGBANK |
| Protein Binding | 32.0 | % | 32 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 800.0 | mg/day | 800 | mg/day | PO, oral;intravenous injection, IV; | Ocuflox | ofloxacin | PDR |
| Max dose for elderly | 800.0 | mg/day | 800 | mg/day | PO, oral;intravenous injection, IV; | Ocuflox | ofloxacin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1