Basic Information
| Drug ID | DDPD01156 |
|
| Drug Name | Bupropion | |
| Molecular Weight | 239.741 | |
| Molecular Formula | C13H18ClNO | |
| CAS Number | 34911-55-2 | |
| SMILES | CC(NC(C)(C)C)C(=O)C1=CC(Cl)=CC=C1 | |
| External Links | ||
| DRUGBANK | DB01156 | |
| T3DB | T3D2999 | |
| PubChem Compound | 444 | |
| PDR | 1211 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.6 | - | 3.6 | - | DRUGBANK |
| Melting Point | 233.5 | ℃ | 233-234 | ℃ | DRUGBANK |
| Water Solubility | 312000.0 | mg/L | 312 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 141.0 | ng/ml | 141±19 | ng/ml | Oral single dose; immediate release formulation; Male, men; adults; normal,healthy; | The Pharmacological Basis of Therapeutics | C Max | 142.0 | ng/ml | 142±28 | ng/ml | Oral single dose; Sustained Release formulation; Male, men; adults; normal,healthy; | The Pharmacological Basis of Therapeutics |
| T Max | 2.0 | h | 2 | h | Tablet, PO, oral; immediate release formulation; | DRUGBANK | T Max | 3.0 | h | 3 | h | Tablet, PO, oral; Sustained Release formulation; | DRUGBANK | T Max | 5.0 | h | 5 | h | Tablet, PO, oral; extended release formulation; | DRUGBANK | T Max | 1.6 | h | 1.6±0.1 | h | Oral single dose; immediate release formulation; Male, men; adults; normal,healthy; | The Pharmacological Basis of Therapeutics | T Max | 3.1 | h | 3.1±0.3 | h | Oral single dose; Sustained Release formulation; Male, men; adults; normal,healthy; | The Pharmacological Basis of Therapeutics |
| Clearance | 2.2 | L/h/kg | 36.0±2.2 | ml/min/kg | apparent clearance; hydrolysis; normal,healthy; Male, men; adults; | Elderly ↓ ;Hepatitis, Hep ↓ ;Alcohol → ; | The Pharmacological Basis of Therapeutics |
| Volume of Distribution | 18.6 | L/kg | 18.6±1.2 | L/kg | Steady state volume of distribution; at steady state; hydrolysis; normal,healthy; Male, men; adults; | Alcohol → ; | The Pharmacological Basis of Therapeutics |
| Half-life | 24.0 | h | 24 | h | DRUGBANK | Half-life | 11.0 | h | 11±1(7.9-18.4) | h | normal,healthy; PO, oral; terminal half-life; adults; Female, women; | alcoholic liver disease ↑ ;Age ↑ ; | The Pharmacological Basis of Therapeutics |
| Eliminate Route | 87.0 | % | 87 | % | Urinary excretion; PO, oral; human, homo sapiens; | DRUGBANK | Eliminate Route | 10.0 | % | 10 | % | Faeces excretion; PO, oral; human, homo sapiens; | DRUGBANK | Eliminate Route | 1.0 | % | <1 | % | Urinary excretion; adults; Male, men; normal,healthy; human, homo sapiens; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 84.0 | % | 84 | % | plasma proteins; high protein binding; human, homo sapiens; | DRUGBANK | Protein Binding | 80.0 | % | >80 | % | adults; Male, men; normal,healthy; human, homo sapiens; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 300.0 | mg/day | 300 | mg/day | Tablet,PO，oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adolescents | 300.0 | mg/day | 300 | mg/day | Tablet,PO，oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adolescents | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adolescents | 300.0 | mg/day | 300 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 450.0 | mg/day | 450 | mg/day | Tablet,PO，oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 150.0 | mg/dose | 150 | mg/dose | Tablet,PO，oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 400.0 | mg/day | 400 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 200.0 | mg/dose | 200 | mg/dose | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 150.0 | mg/dose | 150 | mg/dose | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 450.0 | mg/day | 450 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 522.0 | mg/day | 522 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 522.0 | mg/dose | 522 | mg/dose | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for adults | 450.0 | mg/day | 450 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 450.0 | mg/day | 450 | mg/day | Tablet,PO，oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 150.0 | mg/dose | 150 | mg/dose | Tablet,PO，oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 400.0 | mg/day | 400 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 200.0 | mg/dose | 200 | mg/dose | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 300.0 | mg/day | 300 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 150.0 | mg/dose | 150 | mg/dose | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 450.0 | mg/day | 450 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 522.0 | mg/day | 522 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 522.0 | mg/dose | 522 | mg/dose | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
| Max dose for geriatric | 450.0 | mg/day | 450 | mg/day | PO, oral | Wellbutrin XL | bupropion hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1