Basic Information
| Drug ID | DDPD01151 |
|
| Drug Name | Desipramine | |
| Molecular Weight | 266.3807 | |
| Molecular Formula | C18H22N2 | |
| CAS Number | 50-47-5 | |
| SMILES | CNCCCN1C2=CC=CC=C2CCC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB01151 | |
| T3DB | T3D2996 | |
| PubChem Compound | 2995 | |
| PDR | 1909 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -4.67 | - | -4.67 | - | ADME Research, USCD |
| Log P | 4.9 | - | 4.9 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 216.0 | ℃ | 214-218 | ℃ | DRUGBANK |
| Water Solubility | 58.6 | mg/L | 58.6 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 10.4 | - | 10.4 | - | SANGSTER (1994) |
| Log S | -3.66 | - | -3.66 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | ~100 | % | DRUGBANK | |
| T Max | 5.0 | h | 4-6 | h | DRUGBANK | |
| Clearance | 0.66 | L/h/kg | 11 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 15.0 | L/kg | 15 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 33.5 | h | 7-60 | h | elimination half-life; | DRUGBANK | Half-life | 22.0 | h | 22 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 290.0 | mg/kg | 290.0 | mg/kg | Male, men; mouse; | DRUGBANK | Toxicity LD50 | 320.0 | mg/kg | 320.0 | mg/kg | Female, women; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 290.0 | mg/kg | 290.0 | mg/kg | mouse; | T3DB | Toxicity LD50 | 320.0 | mg/kg | 320.0 | mg/kg | Rattus, Rat; | T3DB |
| Eliminate Route | 70.0 | % | 70 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 82.5 | % | 73-92 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 5.0 | mg/kg/day | 5 | mg/kg/day | PO, oral | Norpramin | desipramine hydrochloride | PDR |
| Max dose for children | 3.0 | mg/kg/day | 3 | mg/kg/day | PO, oral | Norpramin | desipramine hydrochloride | PDR |
| Max dose for adolescents | 150.0 | mg/day | 150 | mg/day | PO, oral | Norpramin | desipramine hydrochloride | PDR |
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | PO, oral | Norpramin | desipramine hydrochloride | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Norpramin | desipramine hydrochloride | PDR |
| Max dose for elderly | 150.0 | mg/day | 150 | mg/day | PO, oral | Norpramin | desipramine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1