Basic Information
| Drug ID | DDPD01149 |
|
| Drug Name | Nefazodone | |
| Molecular Weight | 470.007 | |
| Molecular Formula | C25H32ClN5O2 | |
| CAS Number | 83366-66-9 | |
| SMILES | CCC1=NN(CCCN2CCN(CC2)C2=CC(Cl)=CC=C2)C(=O)N1CCOC1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB01149 | |
| T3DB | T3D2995 | |
| PubChem Compound | 4449 | |
| PDR | 661 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.7 | - | 4.7 | - | DRUGBANK |
| Melting Point | 83.5 | ℃ | 83.5 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | ~100 | % | DRUGBANK | |
| Bioavailability | 20.0 | % | 20 | % | DRUGBANK | |
| Clearance | 0.45 | L/h/kg | 7.5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.55 | L/kg | 0.22-0.87 | L/kg | DRUGBANK | Volume of Distribution | 0.51 | L/kg | 0.51 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.0 | h | 2-4 | h | DRUGBANK | Half-life | 1.2 | h | 1.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 1.0 | % | <1 | % | Urinary excretion; PO, oral; Unchanged drug; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | plasma proteins; high protein binding; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 300.0 | mg/day | 300 | mg/day | PO, oral | Nefazodone | nefazodone hydrochloride | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | Nefazodone | nefazodone hydrochloride | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral | Nefazodone | nefazodone hydrochloride | PDR |
| Max dose for elderly | 600.0 | mg/day | 600 | mg/day | PO, oral | Nefazodone | nefazodone hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1