Basic Information
| Drug ID | DDPD01143 |
|
| Drug Name | Amifostine | |
| Molecular Weight | 214.223 | |
| Molecular Formula | C5H15N2O3PS | |
| CAS Number | 20537-88-6 | |
| SMILES | NCCCNCCSP(O)(O)=O | |
| External Links | ||
| DRUGBANK | DB01143 | |
| PubChem Compound | 2141 | |
| PDR | 2014 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.9 | - | -1.9 | - | DRUGBANK |
| Water Solubility | 1000000.0 | mg/L | 1000 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 1.8 | L/h/kg | 30.65 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.0900 | L/kg | 0.09 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.13 | h | 8 | min | DRUGBANK | Half-life | 0.15 | h | 0.15 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 826.0 | mg/kg | 826.0 | mg/kg | Rattus, Rat; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 910.0 | mg/m2 | 910 | mg/m2 | intravenous injection, IV | Ethyol | amifostine | PDR |
| Max dose for geriatric | 910.0 | mg/m2 | 910 | mg/m2 | intravenous injection, IV | Ethyol | amifostine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1