Basic Information
| Drug ID | DDPD01141 |
|
| Drug Name | Micafungin | |
| Molecular Weight | 1270.274 | |
| Molecular Formula | C56H71N9O23S | |
| CAS Number | 235114-32-6 | |
| SMILES | CCCCCOC1=CC=C(C=C1)C1=CC(=NO1)C1=CC=C(C=C1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)C1=CC(OS(O)(=O)=O)=C(O)C=C1)[C@H](O)CC(N)=O | |
| External Links | ||
| DRUGBANK | DB01141 | |
| PubChem Compound | 477468 | |
| PDR | 2106 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.5 | - | -1.5 | - | DRUGBANK |
| Water Solubility | 200000.0 | mg/L | >200 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 0 | % | 0 | % | PO, oral; | DRUGBANK |
| Clearance | 0.0215 | L/h/kg | 0.359±0.179 | ml/min/kg | Drug combination; patients; adults; | DRUGBANK | Clearance | 0.0193 | L/h/kg | 0.321±0.098 | ml/min/kg | Drug combination; AIDS,HIV; patients; | DRUGBANK | Clearance | 0.0196 | L/h/kg | 0.327±0.093 | ml/min/kg | Drug combination; AIDS,HIV; patients; | DRUGBANK | Clearance | 0.0204 | L/h/kg | 0.340±0.092 | ml/min/kg | Drug combination; AIDS,HIV; patients; | DRUGBANK | Clearance | 0.0128 | L/h/kg | 0.214±0.031 | ml/min/kg | hematopoietic stem cell transplant; patients; | DRUGBANK | Clearance | 0.0122 | L/h/kg | 0.204±0.036 | ml/min/kg | hematopoietic stem cell transplant; patients; | DRUGBANK | Clearance | 0.0134 | L/h/kg | 0.224±0.064 | ml/min/kg | hematopoietic stem cell transplant; patients; | DRUGBANK | Clearance | 0.0134 | L/h/kg | 0.223±0.081 | ml/min/kg | hematopoietic stem cell transplant; patients; | DRUGBANK | Clearance | 0.0102 | L/h/kg | 0.17 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.39 | L/kg | 0.39±0.11 | L/kg | esophageal candidiasis; patients; adults; | DRUGBANK | Volume of Distribution | 0.21 | L/kg | 0.21 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 15.5 | h | 14-17 | h | DRUGBANK | Half-life | 16.0 | h | 16 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 125.0 | mg/kg | 125.0 | mg/kg | intravenous injection, IV; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 200.0 | mg/kg | >200 | mg/kg | intravenous injection, IV; dog; | DRUGBANK |
| Toxicity LDLo | 125.0 | mg/kg | 125.0 | mg/kg | Rattus, Rat; | DRUGBANK |
| Eliminate Route | 71.0 | % | 71 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | high protein binding; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 4.0 | mg/kg/day | 4 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for neonates | 15.0 | mg/kg/day | 15 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for infants | 3.0 | mg/kg/day | 3 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for infants | 4.5 | mg/kg/day | 4.5 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for infants | 4.0 | mg/kg/day | 4 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for infants | 4.5 | mg/kg/day | 4.5 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for children | 2.5 | mg/kg/day | 2.5 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for children | 150.0 | mg/day | 150 | mg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for children | 4.5 | mg/kg/day | 4.5 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for children | 225.0 | mg/day | 225 | mg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for children | 3.0 | mg/kg/day | 3 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for children | 4.5 | mg/kg/day | 4.5 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for adolescents | 2.5 | mg/kg/day | 2.5 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for adolescents | 150.0 | mg/day | 150 | mg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for adolescents | 4.5 | mg/kg/day | 4.5 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for adolescents | 225.0 | mg/day | 225 | mg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for adolescents | 3.0 | mg/kg/day | 3 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for adolescents | 4.5 | mg/kg/day | 4.5 | mg/kg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for adults | 150.0 | mg/day | 150 | mg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
| Max dose for geriatric | 150.0 | mg/day | 150 | mg/day | intravenous injection, IV | Mycamine | micafungin sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1