Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01136 ...
Drug Name Carvedilol
Molecular Weight 406.4742
Molecular Formula C24H26N2O4
CAS Number 72956-09-3
SMILES COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2
External Links
DRUGBANK DB01136
PubChem Compound 2585
PDR 182
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.8 - 3.8 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361727/
Melting Point 114.5 ℃ 114.5 ℃ http://www.chemspider.com/Chemical-Structure.2487.html
Water Solubility 88000.0 mg/L 88 mg/ml http://www.chemspider.com/Chemical-Structure.2487.html

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 1158.5 ng.h/ml 717-1600 ug.h/L PO, oral; DRUGBANK
AUC 609.5 ng.h/ml 272-947 ug.h/L PO, oral; DRUGBANK
AUC 216.5 ng.h/ml 208-225 ug.h/L DRUGBANK
Bioavailability 30.0 % 25-35 % PO, oral; DRUGBANK
Bioavailability 25.0 % 25.0 % PO, oral; The Pharmacological Basis of Therapeutics
Bioavailability 15.0 % 15.0 % PO, oral; Optical rotation S; The Pharmacological Basis of Therapeutics
Bioavailability 31.0 % 31.0 % PO, oral; Optical rotation R; The Pharmacological Basis of Therapeutics
C Max 192.0 ng/ml 122-262 ug/L PO, oral; DRUGBANK
C Max 87.5 ng/ml 24-151 ug/L PO, oral; DRUGBANK
C Max 63.5 ng/ml 58-69 ug/L DRUGBANK
C Max 105.0 ng/ml 105±12 ng/ml PO, oral; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.5 h 1-2 h PO, oral; DRUGBANK
T Max 1.3 h 1.3±0.3 h PO, oral; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.52 L/kg 0.52 L/kg Plasma clearance; DRUGBANK
Clearance 0.52 L/h/kg 8.7±1.7 ml/min/kg Elderly → ;Hepatitis, Hep ↓ ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 0.47 L/h/kg 7.8 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.8 L/kg 1.5-2 L/kg DRUGBANK
Volume of Distribution 1.5 L/kg 1.5±0.3 L/kg Hepatitis, Hep ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.3 L/kg 1.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 8.5 h 7-10 h DRUGBANK
Half-life 2.2 h 2.2±0.3 h Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia → ;Age → ; The Pharmacological Basis of Therapeutics
Half-life 6.0 h 6 h low concentration; The Pharmacological Basis of Therapeutics
Half-life 2.4 h 2.4 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 16.0 % 16 % Urinary excretion; DRUGBANK
Eliminate Route 2.0 % <2 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 98.0 % 98 % plasma proteins; DRUGBANK
Protein Binding 95.0 % 95 % DRUGBANK
Protein Binding 95.0 % 95 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 2.0 mg/kg/day 2 mg/kg/day PO, oral Coreg carvedilol PDR
Max dose for infants 0.9 mg/kg/day 0.9 mg/kg/day PO, oral Coreg carvedilol PDR
Max dose for children 50.0 mg/day 50 mg/day PO, oral Coreg carvedilol PDR
Max dose for children 0.9 mg/kg/day 0.9 mg/kg/day PO, oral Coreg carvedilol PDR
Max dose for adolescents 50.0 mg/day 50 mg/day PO, oral Coreg carvedilol PDR
Max dose for adolescents 0.9 mg/kg/day 0.9 mg/kg/day PO, oral Coreg carvedilol PDR
Max dose for adults 50.0 mg/day 50 mg/day PO, oral Coreg carvedilol PDR
Max dose for adults 100.0 mg/day 100 mg/day PO, oral Coreg carvedilol PDR
Max dose for adults 80.0 mg/day 80 mg/day Capsule, PO, Oral Coreg carvedilol PDR
Max dose for geriatric 50.0 mg/day 50 mg/day PO, oral Coreg carvedilol PDR
Max dose for geriatric 100.0 mg/day 100 mg/day PO, oral Coreg carvedilol PDR
Max dose for geriatric 80.0 mg/day 80 mg/day Capsule, PO, Oral Coreg carvedilol PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1