Basic Information
| Drug ID | DDPD01133 |
|
| Drug Name | Tiludronic acid | |
| Molecular Weight | 318.608 | |
| Molecular Formula | C7H9ClO6P2S | |
| CAS Number | 89987-06-4 | |
| SMILES | OP(O)(=O)C(SC1=CC=C(Cl)C=C1)P(O)(O)=O | |
| External Links | ||
| DRUGBANK | DB01133 | |
| PubChem Compound | 60937 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -3.8 | - | -3.8 | - | https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020707ap_skelid_statr_clnphrmr.pdf |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 27200.0 | ng.h/ml | 27.2±9.0 | mg.h/l | PO, oral; | DRUGBANK |
| Bioavailability | 6.0 | % | 6（2-11） | % | PO, oral; | DRUGBANK |
| C Max | 3350.0 | ng/ml | 3.35±1.07 | mg/L | PO, oral; | DRUGBANK |
| T Max | 1.3 | h | 0.9-1.7 | h | PO, oral; | DRUGBANK |
| Clearance | 0.68 | L/h | 0.68 | L/h | Renal clearance; normal,healthy; | DRUGBANK | Clearance | 0.47 | L/h | 0.47 | L/h | Renal clearance; Paget's disease; | DRUGBANK |
| Volume of Distribution | 45.0 | L | 30-60 | L | DRUGBANK | |
| Half-life | 150.0 | h | 150 | h | elimination half-life; | DRUGBANK | Half-life | 40.0 | h | ~40 | h | terminal half-life; | DRUGBANK |
| Eliminate Route | 60.0 | % | 60 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 90.0 | % | ~90 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1