Basic Information
| Drug ID | DDPD01129 |
|
| Drug Name | Rabeprazole | |
| Molecular Weight | 359.443 | |
| Molecular Formula | C18H21N3O3S | |
| CAS Number | 117976-89-3 | |
| SMILES | COCCCOC1=C(C)C(CS(=O)C2=NC3=CC=CC=C3N2)=NC=C1 | |
| External Links | ||
| DRUGBANK | DB01129 | |
| PubChem Compound | 5029 | |
| PDR | 136 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.6 | - | 0.6 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 52.0 | % | 52 | % | DRUGBANK | |
| Clearance | 0.24 | L/h/kg | 4 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.22 | L/kg | 0.22 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.5 | h | 1-2 | h | DRUGBANK | Half-life | 1.0 | h | 1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 90.0 | % | ~90 | % | Urinary excretion; Oral single dose; | DRUGBANK |
| Protein Binding | 96.3 | % | 96.3 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 20.0 | mg/day | 20 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for children | 40.0 | mg/day | 40 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for children | 10.0 | mg/day | 10 | mg/day | Capsule, PO, Oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for children | 2.5 | mg/kg/day | 2.5 | mg/kg/day | Capsule, PO, Oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for children | 40.0 | mg/day | 40 | mg/day | Capsule, PO, Oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for adolescents | 20.0 | mg/day | 20 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for adults | 80.0 | mg/day | 80 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for adults | 120.0 | mg/day | 120 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for geriatric | 80.0 | mg/day | 80 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
| Max dose for geriatric | 120.0 | mg/day | 120 | mg/day | PO, oral | Aciphex | rabeprazole sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1