Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01128 ...
Drug Name Bicalutamide
Molecular Weight 430.373
Molecular Formula C18H14F4N2O4S
CAS Number 90357-06-5
SMILES CC(O)(CS(=O)(=O)C1=CC=C(F)C=C1)C(=O)NC1=CC(=C(C=C1)C#N)C(F)(F)F
External Links
DRUGBANK DB01128
T3DB T3D4818
PubChem Compound 2375
PDR 2161
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.5 - 2.5 - DRUGBANK
Melting Point 192.0 ℃ 191-193 ℃ DRUGBANK
Water Solubility 5.0 mg/L 5 mg/L DRUGBANK
pKa 12.0 - 12 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 734.0 ng/ml 734.0 ng/ml Oral single dose; Optical rotation R; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 84.0 ng/ml 84.0 ng/ml Oral single dose; Optical rotation S; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 8900.0 ng/ml 8.9±3.5 mcg/ml Oral multiple dose; Optical rotation R/S; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 23.4 h 23.4 h PO, oral; Optical rotation R; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 20.7 h 20.7 h PO, oral; Optical rotation S; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.32 L/h 0.32 L/h apparent clearance; PO, oral; normal,healthy; Male, men; DRUGBANK
Clearance 0.002580 L/h/kg 0.043±0.013 ml/min/kg apparent clearance; PO, oral; Elderly → ;hepatopathy，LD → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 0.44 L/h/kg 7.3±4.0 ml/min/kg apparent clearance; PO, oral; Elderly → ;hepatopathy，LD → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Half-life 141.6 h 5.9 day DRUGBANK
Half-life 139.0 h 139±32 h Optical rotation R; severe hepatic impairment ↑ ; The Pharmacological Basis of Therapeutics
Half-life 29.0 h 29±8.6 h Optical rotation S; chronic liver disease ↑ ; The Pharmacological Basis of Therapeutics
Eliminate Route 1.7 % 1.7±0.3 % Urinary excretion; Male, men; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 96.0 % 96 % DRUGBANK
Protein Binding 96.0 % 96 % Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 50.0 mg/day 50 mg/day PO, oral Casodex bicalutamide PDR
Max dose for elderly 50.0 mg/day 50 mg/day PO, oral Casodex bicalutamide PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1