Basic Information
| Drug ID | DDPD01126 |
|
| Drug Name | Dutasteride | |
| Molecular Weight | 528.5297 | |
| Molecular Formula | C27H30F6N2O2 | |
| CAS Number | 164656-23-9 | |
| SMILES | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])NC(=O)C=C[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)NC1=CC(=CC=C1C(F)(F)F)C(F)(F)F | |
| External Links | ||
| DRUGBANK | DB01126 | |
| PubChem Compound | 6918296 | |
| PDR | 176 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.8 | - | 6.8 | - | Human Metabolome Database |
| Melting Point | 246.0 | ℃ | 242-250 | ℃ | MSDS, FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 60.0 | % | 60(40-94) | % | PO, oral; normal,healthy; | DRUGBANK |
| Css | 40.0 | ng/ml | 40.0 | ng/ml | Oral multiple dose; | DRUGBANK |
| Tss | 4320.0 | h | 6 | month | Oral multiple dose; | DRUGBANK |
| Clearance | 0.58 | L/h | 0.58 | L/h | PO, oral; Single dose; normal,healthy; | DRUGBANK |
| Volume of Distribution | 400.0 | L | 300-500 | L | DRUGBANK | |
| Half-life | 840.0 | h | ~5 | week | elimination half-life; at steady state; | DRUGBANK | Half-life | 3600.0 | h | 4-6 | month | terminal half-life; | DRUGBANK |
| Toxicity LD50 | 2000.0 | mg/kg | >2000 | mg/kg | skin/dermal; rabbit; | DRUGBANK |
| Eliminate Route | 8.0 | % | ~1-15 | % | Faeces excretion; Unchanged drug; | DRUGBANK | Eliminate Route | 1.0 | % | <1 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 99.0 | % | ~99 | % | DRUGBANK | Protein Binding | 96.6 | % | 96.6 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1