Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01124 ...
Drug Name Tolbutamide
Molecular Weight 270.348
Molecular Formula C12H18N2O3S
CAS Number 64-77-7
SMILES CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1
External Links
DRUGBANK DB01124
PubChem Compound 5505
PDR 1800
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.34 - 2.34 - HANSCH,C ET AL. (1995)
Melting Point 128.5 ℃ 128.5 ℃ PhysProp
Water Solubility 109.0 mg/L 109 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
pKa 5.16 - 5.16 - SANGSTER (1994)
Log S -3.39 - -3.39 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 85.0 % 80-90 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 53000.0 ng/ml 53±12 mcg/ml Oral single dose; The Pharmacological Basis of Therapeutics
T Max 4.0 h 3-5 h Oral single dose; DRUGBANK
T Max 3.1 h 3.1±1.5 h Oral single dose; The Pharmacological Basis of Therapeutics
Clearance 0.0132 L/h/kg 0.22±0.06 ml/min/kg apparent clearance; PO, oral; hydrolysis; acute viral hepatitis AVH ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.0126 L/h/kg 0.21 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.12 L/kg 0.12±0.02 L/kg Apparent volume of distribution; PO, oral; acute viral hepatitis AVH → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.12 L/kg 0.12 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 7.0 h ~7(4-25) h DRUGBANK
Half-life 5.9 h 5.9±1.4 h PO, oral; acute viral hepatitis AVH ↓ ;chronic respiratory insufficiency ↓ ;RD, renal impairment, Renal disease，including uremia → ;Age → ; The Pharmacological Basis of Therapeutics
Half-life 7.0 h 7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2600.0 mg/kg 2600.0 mg/kg PO, oral; mouse; DRUGBANK
Eliminate Route 80.0 % ~75-85 % Urinary excretion; Oral single dose; DRUGBANK
Eliminate Route 0.10 % ~0.1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 95.0 % ~95 % plasma proteins; DRUGBANK
Protein Binding 93.5 % 91-96 % Elderly ↓ ;acute viral hepatitis AVH ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 3000.0 mg/day 3000 mg/day PO, oral Tolbutamide tolbutamide PDR
Max dose for geriatric 3000.0 mg/day 3000 mg/day PO, oral Tolbutamide tolbutamide PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1