Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.6 | - | 2.6 | - | DRUGBANK |
| Melting Point | 181.0 | ℃ | 180-182 | ℃ | U.S. Patent 3,501,495 |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 5.0 | h | 4-6 | h | PO, oral; | DRUGBANK |
| Metabolic | 1.0 | % | <1 | % | Urinary excretion; Unchanged drug; PO, oral; | DRUGBANK |
| Clearance | 0.0246 | L/h/kg | 0.41 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.43 | L/kg | 0.43 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 10.4 | null | 10.4 | null | DRUGBANK | Half-life | 16.4 | h | 16.4 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 3000.0 | mg/kg | 3000.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 65.0 | % | 60-70 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 15.0 | % | 10-20 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 94.0 | % | 94 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1