Basic Information
| Drug ID | DDPD01117 |
|
| Drug Name | Atovaquone | |
| Molecular Weight | 366.837 | |
| Molecular Formula | C22H19ClO3 | |
| CAS Number | 95233-18-4 | |
| SMILES | OC1=C([C@H]2CC[C@@H](CC2)C2=CC=C(Cl)C=C2)C(=O)C2=CC=CC=C2C1=O | |
| External Links | ||
| DRUGBANK | DB01117 | |
| PubChem Compound | 74989 | |
| PDR | 213 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.8 | - | 5.8 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 23.0 | % | 23 | % | PO, oral; | DRUGBANK | Bioavailability | 47.0 | % | 47 | % | PO, oral; food; | food ↑ ; | DRUGBANK |
| Clearance | 0.62 | L/h | 10.4±5.5 | ml/min | intravenous injection, IV; AIDS,HIV; patients; | DRUGBANK | Clearance | 0.009000 | L/h/kg | 0.15 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.60 | L/kg | 0.60±0.17 | L/kg | DRUGBANK | Volume of Distribution | 0.60 | L/kg | 0.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 64.8 | h | 2.2-3.2 | day | DRUGBANK | Half-life | 63.0 | h | 63 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 0.60 | % | <0.6 | % | Urinary excretion; | DRUGBANK | |
| Protein Binding | 99.9 | % | 99.9 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Mepron | atovaquone | PDR |
| Max dose for infants | 45.0 | mg/kg/day | 45 | mg/kg/day | PO, oral | Mepron | atovaquone | PDR |
| Max dose for infants | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Mepron | atovaquone | PDR |
| Max dose for children | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Mepron | atovaquone | PDR |
| Max dose for children | 1500.0 | mg/day | 1.5 | g/day | PO, oral | Mepron | atovaquone | PDR |
| Max dose for children | 45.0 | mg/kg/day | 45 | mg/kg/day | PO, oral | Mepron | atovaquone | PDR |
| Max dose for adolescents | 3000.0 | mg/day | 3 | g/day | PO, oral | Mepron | atovaquone | PDR |
| Max dose for adults | 3000.0 | mg/day | 3 | g/day | PO, oral | Mepron | atovaquone | PDR |
| Max dose for geriatric | 3000.0 | mg/day | 3 | g/day | PO, oral | Mepron | atovaquone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1