Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01115 ...
Drug Name Nifedipine
Molecular Weight 346.3346
Molecular Formula C17H18N2O6
CAS Number 21829-25-4
SMILES COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OC
External Links
DRUGBANK DB01115
PubChem Compound 4485
PDR 1481
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.2 - 2.2 - MASUMOTO,K ET AL. (1995)
Melting Point 173.0 ℃ 172-174 ℃ PhysProp

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % ~100 % PO, oral; DRUGBANK
AUC 25.0 ng.h/ml 25.0 ng.h/ml sublingual; DRUGBANK
AUC 152.0 ng.h/ml 152.0 ng.h/ml PO, oral; DRUGBANK
Bioavailability 56.5 % 45-68 % PO, oral; DRUGBANK
Bioavailability 50.0 % 50±13 % The Pharmacological Basis of Therapeutics
C Max 10.0 ng/ml 10 ng/ml sublingual; DRUGBANK
C Max 82.0 ng/ml 82 ng/ml PO, oral; DRUGBANK
C Max 79.0 ng/ml 79±44 ng/ml Capsule, PO, Oral; immediate release formulation; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 42.0 ng/ml 35-49 ng/ml PO, oral; extended release formulation; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.83 h 50 min sublingual; DRUGBANK
T Max 0.47 h 28 min PO, oral; DRUGBANK
T Max 0.50 h 0.5±0.2 h Capsule, PO, Oral; immediate release formulation; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 6.0 h ~6 h PO, oral; extended release formulation; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 34.5 L/h 450-700 ml/min Total clearance; DRUGBANK
Clearance 0.42 L/h/kg 7.0±1.8 ml/min/kg hydrolysis; Elderly ↓ ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia → ;Somking → ; The Pharmacological Basis of Therapeutics
Clearance 0.44 L/h/kg 7.3 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.70 L/kg 0.62-0.77 L/kg Apparent volume of distribution; DRUGBANK
Volume of Distribution 0.27 L/kg 0.25-0.29 L/kg Total volume of distribution; DRUGBANK
Volume of Distribution 0.78 L/kg 0.78±0.22 L/kg Elderly ↓ ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Somking → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.79 L/kg 0.79 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.0 h ~2 h elimination half-life; DRUGBANK
Half-life 1.8 h 1.8±0.4 h Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ;Age ↑ ;Somking → ; The Pharmacological Basis of Therapeutics
Half-life 1.9 h 1.9 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 1022.0 mg/kg 1022.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 202.0 mg/kg 202.0 mg/kg PO, oral; mouse; DRUGBANK
Eliminate Route 70.0 % 60-80 % Urinary excretion; DRUGBANK
Eliminate Route 0 % ~0 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 95.0 % 92-98 % DRUGBANK
Protein Binding 96.0 % 96±1 % RD, renal impairment, Renal disease，including uremia ↓ ;Hepatic cirrhosis, cirr ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 3.0 mg/kg/day 3 mg/kg/day Tablet,PO，oral Nifedipine nifedipine PDR
Max dose for children 180.0 mg/day 180 mg/day Tablet,PO，oral Nifedipine nifedipine PDR
Max dose for children 0.5 mg/kg/dose 0.5 mg/kg/dose Nifedipine nifedipine PDR
Max dose for children 10.0 mg/dose 10 mg/dose Nifedipine nifedipine PDR
Max dose for adolescents 3.0 mg/kg/day 3 mg/kg/day PO, oral Nifedipine nifedipine PDR
Max dose for adolescents 180.0 mg/day 180 mg/day PO, oral Nifedipine nifedipine PDR
Max dose for adolescents 0.5 mg/kg/dose 0.5 mg/kg/dose Nifedipine nifedipine PDR
Max dose for adolescents 10.0 mg/dose 10 mg/dose Nifedipine nifedipine PDR
Max dose for adults 90.0 mg/day 90 mg/day PO, oral Nifedipine nifedipine PDR
Max dose for adults 180.0 mg/day 180 mg/day Capsule, PO, Oral Nifedipine nifedipine PDR
Max dose for adults 90.0 mg/day 90 mg/day Tablet,PO，oral Nifedipine nifedipine PDR
Max dose for adults 120.0 mg/day 120 mg/day PO, oral Nifedipine nifedipine PDR
Max dose for elderly 90.0 mg/day 90 mg/day PO, oral Nifedipine nifedipine PDR
Max dose for elderly 180.0 mg/day 180 mg/day Capsule, PO, Oral Nifedipine nifedipine PDR
Max dose for elderly 90.0 mg/day 90 mg/day Tablet,PO，oral Nifedipine nifedipine PDR
Max dose for elderly 120.0 mg/day 120 mg/day PO, oral Nifedipine nifedipine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1