Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01114 ...
Drug Name Chlorpheniramine
Molecular Weight 274.788
Molecular Formula C16H19ClN2
CAS Number 132-22-9
SMILES CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1
External Links
DRUGBANK DB01114
T3DB T3D2989
PubChem Compound 2725
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.38 - 3.38 - HANSCH,C ET AL. (1995)
Boiling Point 142.0 ℃ 142 ℃ DRUGBANK
Water Solubility 5500.0 mg/L 5500 mg/L BEILSTEIN
pKa 9.13 - 9.13 - PERRIN,DD (1965)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 41.0 % 41±16 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 43.5 ng/ml 16-71 ng/ml PO, oral; immediate release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 46.5 ng/ml 17-76 ng/ml PO, oral; Sustained Release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.5 h 2-3 h PO, oral; immediate release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 6.9 h 5.7-8.1 h PO, oral; Sustained Release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.10 L/h/kg 1.7±0.1 ml/min/kg Children ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.15 L/h/kg 2.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 3.2 L/kg 3.2±0.3 L/kg Children → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.3 L/kg 3.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 24.0 h 21-27 h DRUGBANK
Half-life 20.0 h 20±5 h Children ↓ ; The Pharmacological Basis of Therapeutics
Half-life 22.0 h 22 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 306.0 mg/kg 306.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 130.0 mg/kg 130.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 198.0 mg/kg 198.0 mg/kg PO, oral; guinea pigs; DRUGBANK
Toxicity LD50 306.0 mg/kg 306.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 130.0 mg/kg 130.0 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 198.0 mg/kg 198.0 mg/kg PO, oral; guinea pigs; T3DB
Toxicity LD50 306.0 mg/kg 306.0 mg/kg human, homo sapiens; T3DB
Eliminate Route 13.2 % 0.3-26 % Urinary excretion; Raceme D/L; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 72.0 % 72 % DRUGBANK
Protein Binding 70.0 % 70±3 % Raceme D/L; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1