Basic Information
| Drug ID | DDPD01112 |
|
| Drug Name | Cefuroxime | |
| Molecular Weight | 424.385 | |
| Molecular Formula | C16H16N4O8S | |
| CAS Number | 55268-75-2 | |
| SMILES | [H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CC=CO1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB01112 | |
| PubChem Compound | 5479529 | |
| PDR | 180 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.16 | - | -0.16 | - | SANGSTER (1993) |
| Melting Point | 221.5 | ℃ | 218-225 | ℃ | DRUGBANK |
| Water Solubility | 145.0 | mg/L | 145 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 37.0 | % | 37 | % | PO, oral; | DRUGBANK | Bioavailability | 52.0 | % | 52 | % | PO, oral; food; | food ↑ ; | DRUGBANK | Bioavailability | 32.0 | % | 32(21-44) | % | PO, oral; | The Pharmacological Basis of Therapeutics |
| C Max | 8500.0 | ng/ml | 7-10 | mcg/ml | Oral single dose; adults; normal,healthy; | The Pharmacological Basis of Therapeutics | |
| T Max | 2.5 | h | 2-3 | h | Oral single dose; adults; normal,healthy; | The Pharmacological Basis of Therapeutics | |
| Clearance | 0.13 | L/h/kg | 2.2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Volume of Distribution | 0.20 | L/kg | 0.20±0.04 | L/kg | Elderly → ;RD, renal impairment, Renal disease，including uremia → ; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.15 | L/kg | 0.15 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.3 | h | ~80 | min | intravenous infusion, IV in drop; | DRUGBANK | Half-life | 1.3 | h | ~80 | min | intravenous injection, IV; | DRUGBANK | Half-life | 1.7 | h | 1.7±0.6 | h | Neonates → ;RD, renal impairment, Renal disease，including uremia ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 1.1 | h | 1.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 96.0 | % | 96±10 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics | |
| Protein Binding | 50.0 | % | 50 | % | DRUGBANK | Protein Binding | 33.0 | % | 33±6 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for neonates | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for infants | 240.0 | mg/kg/day | 240 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for infants | 30.0 | mg/kg/day | 30 | mg/kg/day | PO, oral | Ceftin | cefuroxime axetil | PDR |
| Max dose for infants | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for infants | 30.0 | mg/kg/day | 30 | mg/kg/day | PO, oral | Ceftin | cefuroxime axetil | PDR |
| Max dose for children | 240.0 | mg/kg/day | 240 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for children | 9000.0 | mg/day | 9 | g/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for children | 30.0 | mg/kg/day | 30 | mg/kg/day | PO, oral | Ceftin | cefuroxime axetil | PDR |
| Max dose for children | 1000.0 | mg/day | 1000 | mg/day | PO, oral | Ceftin | cefuroxime axetil | PDR |
| Max dose for adolescents | 240.0 | mg/kg/day | 240 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for adolescents | 9000.0 | mg/day | 9 | g/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for adolescents | 1000.0 | mg/day | 1000 | mg/day | PO, oral | Ceftin | cefuroxime axetil | PDR |
| Max dose for adults | 9000.0 | mg/day | 9 | g/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for adults | 1000.0 | mg/day | 1000 | mg/day | PO, oral | Ceftin | cefuroxime axetil | PDR |
| Max dose for geriatric | 9000.0 | mg/day | 9 | g/day | intravenous injection, IV;IM,intramuscular injection; | Ceftin | cefuroxime axetil | PDR |
| Max dose for geriatric | 1000.0 | mg/day | 1000 | mg/day | PO, oral | Ceftin | cefuroxime axetil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1