Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01111 ...
Drug Name Colistimethate
Molecular Weight 1634.87
Molecular Formula C58H105N16O28S5
CAS Number 12705-41-8
SMILES CCC(C)CCCCC(=O)NC(CCNCS([O-])(=O)=O)C(=O)NC(C(C)O)C(=O)NC(CCNCS([O-])(=O)=O)C(=O)NC1CCNC(=O)C(NC(=O)C(CCNCS([O-])(=O)=O)NC(=O)C(CCNCS([O-])(=O)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCNCS([O-])(=O)=O)NC1=O)C(C)O
External Links
DRUGBANK DB01111
PubChem Compound 70789202
PDR 1996
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Metabolic 80.0 % 80 % Urinary excretion; DRUGBANK
Metabolic 0 % 0 % Bile excretion; DRUGBANK
Half-life 2.5 h 2-3 h intravenous injection, IV; adults; Children; Prem, premature; DRUGBANK
Half-life 2.5 h 2-3 h intravenous infusion, IV in drop; adults; Children; Prem, premature; DRUGBANK
Toxicity LD50 5450.0 mg/kg 5450.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 5.0 mg/kg/day 5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Coly-Mycin M colistimethate sodium PDR
Max dose for infants 5.0 mg/kg/day 5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Coly-Mycin M colistimethate sodium PDR
Max dose for infants 150.0 mg/day 150 mg/day inhalation, IH Coly-Mycin M colistimethate sodium PDR
Max dose for infants 5.0 mg/day 5 mg/day Coly-Mycin M colistimethate sodium PDR
Max dose for children 5.0 mg/kg/day 5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Coly-Mycin M colistimethate sodium PDR
Max dose for children 150.0 mg/day 150 mg/day inhalation, IH Coly-Mycin M colistimethate sodium PDR
Max dose for children 5.0 mg/day 5 mg/day Coly-Mycin M colistimethate sodium PDR
Max dose for adolescents 5.0 mg/kg/day 5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Coly-Mycin M colistimethate sodium PDR
Max dose for adolescents 300.0 mg/day 300 mg/day inhalation, IH Coly-Mycin M colistimethate sodium PDR
Max dose for adolescents 40.0 mg/day 40 mg/day Coly-Mycin M colistimethate sodium PDR
Max dose for geriatric 5.0 mg/kg/day 5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Coly-Mycin M colistimethate sodium PDR
Max dose for geriatric 300.0 mg/day 300 mg/day inhalation, IH Coly-Mycin M colistimethate sodium PDR
Max dose for geriatric 40.0 mg/day 40 mg/day Coly-Mycin M colistimethate sodium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1