Basic Information
| Drug ID | DDPD01100 |
|
| Drug Name | Pimozide | |
| Molecular Weight | 461.5462 | |
| Molecular Formula | C28H29F2N3O | |
| CAS Number | 2062-78-4 | |
| SMILES | FC1=CC=C(C=C1)C(CCCN1CCC(CC1)N1C(=O)NC2=CC=CC=C12)C1=CC=C(F)C=C1 | |
| External Links | ||
| DRUGBANK | DB01100 | |
| T3DB | T3D2984 | |
| PubChem Compound | 16362 | |
| PDR | 1628 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.3 | - | 6.3 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 216.0 | ℃ | 214-218 | ℃ | PhysProp |
| Water Solubility | 10.0 | mg/L | 10 | mg/L | MERCK INDEX 1996) |
| pKa | 8.63 | - | 8.63 | - | EL TAYAR,N ET AL. (1985) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 50.0 | % | >50 | % | PO, oral; | DRUGBANK |
| T Max | 7.0 | h | 6-8 | h | PO, oral; | DRUGBANK |
| Half-life | 29.0 | h | 29±10 | h | Single dose; normal,healthy; | DRUGBANK |
| Toxicity LD50 | 1100.0 | mg/kg | 1100.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 228.0 | mg/kg | 228.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 1100.0 | mg/kg | 1100.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB | Toxicity LD50 | 228.0 | mg/kg | 228.0 | mg/kg | PO, oral; mouse; | T3DB |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 0.2 | mg/kg/day | 0.2 | mg/kg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for children | 10.0 | mg/day | 10 | mg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for children | 0.2 | mg/kg/day | 0.2 | mg/kg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for children | 6.0 | mg/day | 6 | mg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for adolescents | 0.2 | mg/kg/day | 0.2 | mg/kg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for adolescents | 10.0 | mg/day | 10 | mg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for adults | 0.2 | mg/kg/day | 0.2 | mg/kg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for adults | 10.0 | mg/day | 10 | mg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for geriatric | 0.2 | mg/kg/day | 0.2 | mg/kg/day | PO, oral | Orap | pimozide | PDR |
| Max dose for geriatric | 10.0 | mg/day | 10 | mg/day | PO, oral | Orap | pimozide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1