Basic Information
| Drug ID | DDPD01099 |
|
| Drug Name | Flucytosine | |
| Molecular Weight | 129.0925 | |
| Molecular Formula | C4H4FN3O | |
| CAS Number | 2022-85-7 | |
| SMILES | NC1=NC(=O)NC=C1F | |
| External Links | ||
| DRUGBANK | DB01099 | |
| T3DB | T3D2983 | |
| PubChem Compound | 3366 | |
| PDR | 679 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.1 | - | -1.1 | - | DRUGBANK |
| Melting Point | 296.0 | ℃ | 296 | ℃ | PhysProp |
| Water Solubility | 15000.0 | mg/L | 15000 | mg/L | MERCK INDEX 1996) |
| pKa | 3.26 | - | 3.26 | - | BUDAVARI,S ET AL. (1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | ~100 | % | PO, oral; | DRUGBANK |
| Bioavailability | 83.5 | % | 78-89 | % | PO, oral; | DRUGBANK |
| Clearance | 0.12 | L/h/kg | 2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.68 | L/kg | 0.68 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.6 | h | 2.4-4.8 | h | DRUGBANK | Half-life | 4.2 | h | 4.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 15000.0 | mg/kg | 15.0 | g/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 15000.0 | mg/kg | 15.0 | g/kg | PO, oral; Rattus, Rat; | T3DB |
| Protein Binding | 29.5 | % | 28-31 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 150.0 | mg/kg/day | 150 | mg/kg/day | PO, oral | Ancobon | flucytosine | PDR |
| Max dose for neonates | 200.0 | mg/kg/day | 200 | mg/kg/day | PO, oral | Ancobon | flucytosine | PDR |
| Max dose for infants | 150.0 | mg/kg/day | 150 | mg/kg/day | PO, oral | Ancobon | flucytosine | PDR |
| Max dose for children | 150.0 | mg/kg/day | 150 | mg/kg/day | PO, oral | Ancobon | flucytosine | PDR |
| Max dose for adolescents | 150.0 | mg/kg/day | 150 | mg/kg/day | PO, oral | Ancobon | flucytosine | PDR |
| Max dose for adults | 150.0 | mg/kg/day | 150 | mg/kg/day | PO, oral | Ancobon | flucytosine | PDR |
| Max dose for geriatric | 150.0 | mg/kg/day | 150 | mg/kg/day | PO, oral | Ancobon | flucytosine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1