Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01098 ...
Drug Name Rosuvastatin
Molecular Weight 481.538
Molecular Formula C22H28FN3O6S
CAS Number 287714-41-4
SMILES CC(C)C1=NC(=NC(C2=CC=C(F)C=C2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(=O)O)N(C)S(C)(=O)=O
External Links
DRUGBANK DB01098
T3DB T3D2680
PubChem Compound 446157
PDR 2318
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.13 - 0.13 - FDA label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 50.0 % 50 % PO, oral; Male, men; Caucasian; DRUGBANK
Bioavailability 20.0 % 20 % PO, oral; Male, men; Caucasian; DRUGBANK
Bioavailability 20.0 % 20(17-23) % PO, oral; The Pharmacological Basis of Therapeutics
C Max 6.1 ng/ml 6.06 ng/ml PO, oral; normal,healthy; DRUGBANK
C Max 4.6 ng/ml 4.6±2.1 ng/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 5.0 h 5 h PO, oral; normal,healthy; DRUGBANK
T Max 3.0 h 3(1-6) h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 0.63 L/h/kg 10.5±4.7 ml/min/kg normal,healthy; Male, men; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.66 L/h/kg 11 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 134.0 L 134.0 L Average volume of distribution; at steady state; DRUGBANK
Volume of Distribution 1.7 L/kg 1.7±0.5 L/kg normal,healthy; Male, men; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.7 L/kg 1.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 19.0 h ~19 h elimination half-life; dose → ; DRUGBANK
Half-life 20.0 h 20±6 h normal,healthy; Male, men; The Pharmacological Basis of Therapeutics
Half-life 2.0 h 2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 90.0 % 90 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 90.0 % ~90 % Faeces excretion; adults; Male, men; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 10.0 % 10 % Urinary excretion; adults; Male, men; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 30.0 % 30±7 % Urinary excretion; Male, men; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 88.0 % 88 % plasma proteins; Plasma Concentration → ; DRUGBANK
Protein Binding 88.0 % 88 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 20.0 mg/day 20 mg/day Tablet,PO，oral Crestor rosuvastatin calcium PDR
Max dose for adolescents 20.0 mg/day 20 mg/day Tablet,PO，oral Crestor rosuvastatin calcium PDR
Max dose for adults 40.0 mg/day 40 mg/day PO, oral Crestor rosuvastatin calcium PDR
Max dose for geriatric 40.0 mg/day 40 mg/day PO, oral Crestor rosuvastatin calcium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1