Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01095 ...
Drug Name Fluvastatin
Molecular Weight 411.4659
Molecular Formula C24H26FNO4
CAS Number 93957-54-1
SMILES CC(C)N1C(\C=C\[C@H](O)C[C@H](O)CC(O)=O)=C(C2=CC=C(F)C=C2)C2=CC=CC=C12
External Links
DRUGBANK DB01095
PubChem Compound 1548972
PDR 2611
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.5 - 4.5 - DRUGBANK
Melting Point 195.5 ℃ 194-197 ℃ Hojjati, Mohammad; Journal of Supercritical Fluids 2007, V41(2), P187-194 CAPLUS
Water Solubility 0.46 mg/L 0.46 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 90.0 % >90 % DRUGBANK
Bioavailability 24.0 % 24(9-50) % PO, oral; DRUGBANK
Bioavailability 36.0 % 36 % PO, oral; extended release formulation; high-fat meal; extended release formulation ↑ ;high-fat meal ↑ ; DRUGBANK
T Max 1.0 h <1 h PO, oral; DRUGBANK
T Max 6.0 h 6 h PO, oral; extended release formulation; high-fat meal; extended release formulation ↑ ;high-fat meal ↑ ; DRUGBANK
Metabolic 75.0 % 75 % Liver metabolism; Faeces excretion; Bile excretion; DRUGBANK
Metabolic 20.0 % ~20 % Liver metabolism; DRUGBANK
Metabolic 5.0 % ~5 % Liver metabolism; DRUGBANK
Clearance 0.80 L/h/kg 0.8 L/h/kg DRUGBANK
Clearance 107.0 L/h 107±38.1 L/h hypercholesterolemia; Single dose; DRUGBANK
Clearance 87.8 L/h 87.8±45 L/h hypercholesterolemia; Multiple dose; DRUGBANK
Clearance 108.0 L/h 108±44.7 L/h hypercholesterolemia; Single dose; DRUGBANK
Clearance 64.2 L/h 64.2±21.1 L/h hypercholesterolemia; Multiple dose; DRUGBANK
Clearance 0.96 L/h/kg 16 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.35 L/kg 0.35 L/kg DRUGBANK
Volume of Distribution 0.42 L/kg 0.42 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.0 h 3 h DRUGBANK
Half-life 0.70 h 0.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 90.0 % ~90 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 5.0 % ~5 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 1.8 % <1.8 % Faeces excretion; PO, oral; Unchanged drug; DRUGBANK
Protein Binding 98.0 % 98 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 80.0 mg/day 80 mg/day PO, oral Lescol/Lescol XL fluvastatin sodium PDR
Max dose for adolescents 80.0 mg/day 80 mg/day PO, oral Lescol/Lescol XL fluvastatin sodium PDR
Max dose for adults 80.0 mg/day 80 mg/day PO, oral Lescol/Lescol XL fluvastatin sodium PDR
Max dose for geriatric 80.0 mg/day 80 mg/day PO, oral Lescol/Lescol XL fluvastatin sodium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1