Basic Information
| Drug ID | DDPD01088 |
|
| Drug Name | Iloprost | |
| Molecular Weight | 360.494 | |
| Molecular Formula | C22H32O4 | |
| CAS Number | 78919-13-8 | |
| SMILES | [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O | |
| External Links | ||
| DRUGBANK | DB01088 | |
| PubChem Compound | 5311181 | |
| PDR | 1709 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.8 | - | 4.8 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 63.0 | % | 63 | % | DRUGBANK | |
| Clearance | 1.2 | L/h/kg | 20.0 | ml/min/kg | normal,healthy; | DRUGBANK | Clearance | 0.96 | L/h/kg | 16 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.75 | L/kg | 0.7-0.8 | L/kg | DRUGBANK | Volume of Distribution | 0.37 | L/kg | 0.37 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.42 | h | 20-30 | min | DRUGBANK | Half-life | 0.57 | h | 0.57 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 60.0 | % | 60 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 0.07 | mg/day | 70 | mcg/day | Ventavis | iloprost | PDR | |
| Max dose for elderly | 0.07 | mg/day | 70 | mcg/day | Ventavis | iloprost | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1