Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01079 ...
Drug Name Tegaserod
Molecular Weight 301.394
Molecular Formula C16H23N5O
CAS Number 145158-71-0
SMILES CCCCCNC(=N)N\N=C\C1=CNC2=C1C=C(OC)C=C2
External Links
DRUGBANK DB01079
PubChem Compound 5362436
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.6 - 2.6 - DRUGBANK
Melting Point 155.0 ℃ 155 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 10.0 % 10 % fasting; DRUGBANK
Bioavailability 11.0 % 11±2 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 2.7 ng/ml 2.7±1.2 ng/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 1.4 h 0.7-2 h fasting; DRUGBANK
T Max 0.70 h 0.7 h PO, oral; high-fat meal; DRUGBANK
T Max 0.80 h 0.8 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 77.0 L/h 77 ± 15 L/h Plasma clearance; intravenous injection, IV; DRUGBANK
Clearance 1.1 L/h/kg 18±4 ml/min/kg normal,healthy; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Clearance 1.1 L/h/kg 18 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 368.0 L 368±223 L Average volume of distribution; at steady state; intravenous injection, IV; DRUGBANK
Volume of Distribution 5.2 L/kg 5.2±3.2 L/kg normal,healthy; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Volume of Distribution 5.3 L/kg 5.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 6.4 h 4.6-8.1 h elimination half-life; PO, oral; DRUGBANK
Half-life 11.0 h 11±5 h normal,healthy; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Half-life 11.0 h 11 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 66.7 % ~66.7 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 33.3 % ~33.3 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 0 % ~0 % Urinary excretion; PO, oral; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 98.0 % ~98 % DRUGBANK
Protein Binding 98.0 % 98 % human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1