Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01073 ...
Drug Name Fludarabine
Molecular Weight 285.235
Molecular Formula C10H12FN5O4
CAS Number 21679-14-1
SMILES NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
External Links
DRUGBANK DB01073
T3DB T3D4736
PubChem Compound 657237
PDR 3387
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -2.8 - -2.8 - DRUGBANK
Melting Point 260.0 ℃ 260 ℃ DRUGBANK
Water Solubility 3530.0 mg/L 3.53 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 55.0 % 55 % PO, oral; DRUGBANK
C Max 570.0 ng/ml 0.57 mcg/ml adults; tumor; The Pharmacological Basis of Therapeutics
Clearance 7.9 L/h 117-145 ml/min intravenous injection, IV; Single dose; Chronic lymphocytic leukemia; patients; DRUGBANK
Clearance 0.22 L/h/kg 3.7±1.5 ml/min/kg intravenous injection, IV; tumor; patients; Male, men;  Female, women; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.19 L/h/kg 3.2 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 2.4 L/kg 2.4±0.6 L/kg intravenous injection, IV; tumor; patients; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Volume of Distribution 2.2 L/kg 2.2 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 20.0 h 20 h DRUGBANK
Half-life 20.0 h 10-30 h Male, men;  Female, women; adults; tumor; patients; intravenous injection, IV; The Pharmacological Basis of Therapeutics
Half-life 11.0 h 11 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 24.0 % 24±3 % Urinary excretion; intravenous injection, IV; adults; tumor; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 24.0 % 19-29 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 25.0 mg/m2 25 mg/m2 intravenous injection, IV Fludarabine Phosphate for Injection fludarabine phosphate PDR
Max dose for adults 30.0 mg/m2 30 mg/m2 intravenous injection, IV Fludarabine Phosphate for Injection fludarabine phosphate PDR
Max dose for geriatric 25.0 mg/m2 25 mg/m2 intravenous injection, IV Fludarabine Phosphate for Injection fludarabine phosphate PDR
Max dose for geriatric 30.0 mg/m3 30 mg/m3 intravenous injection, IV Fludarabine Phosphate for Injection fludarabine phosphate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1