Basic Information
| Drug ID | DDPD01069 |
|
| Drug Name | Promethazine | |
| Molecular Weight | 284.419 | |
| Molecular Formula | C17H20N2S | |
| CAS Number | 60-87-7 | |
| SMILES | CC(CN1C2=CC=CC=C2SC2=CC=CC=C12)N(C)C | |
| External Links | ||
| DRUGBANK | DB01069 | |
| T3DB | T3D4560 | |
| PubChem Compound | 4927 | |
| PDR | 1286 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.81 | - | 4.81 | - | HANSCH,C ET AL. (1995) |
| Boiling Point | 191.0 | ℃ | 190-192 | ℃ | PhysProp |
| Melting Point | 60.0 | ℃ | 60 | ℃ | PhysProp |
| Water Solubility | 15.6 | mg/L | 15.6 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 9.1 | - | 9.1 | - | SANGSTER (1994) |
| Log S | -4.26 | - | -4.26 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 14466.0 | ng.h/ml | 14466.0 | ng.h/ml | intravenous injection, IV; | DRUGBANK | AUC | 11511.0 | ng.h/ml | 11511.0 | ng.h/ml | PO, oral; | DRUGBANK |
| Bioavailability | 25.0 | % | 25 | % | PO, oral; | DRUGBANK |
| C Max | 22.0 | ng/ml | 22 | ng/ml | IM,intramuscular injection; | DRUGBANK | C Max | 10.0 | ng/ml | 10 | ng/ml | intravenous injection, IV; | DRUGBANK | C Max | 10.2 | ng/ml | 2.4-18.0 | ng/ml | PO, oral; | DRUGBANK |
| T Max | 7.0 | h | 4-10 | h | intravenous injection, IV; | DRUGBANK | T Max | 2.3 | h | 1.5-3 | h | PO, oral; | DRUGBANK |
| Clearance | 68.4 | L/h | ~1.14 | L/min | intravenous injection, IV; | DRUGBANK | Clearance | 0.35 | L/h | 5.9 | ml/min | Renal clearance; | DRUGBANK | Clearance | 5.4 | L/h | 90.4 | ml/min | Renal clearance; | DRUGBANK | Clearance | 0.84 | L/h/kg | 14 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 30.0 | L/kg | ~30 | L/kg | DRUGBANK | Volume of Distribution | 14.0 | L/kg | 14 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 13.5 | h | ~12-15 | h | elimination half-life; | DRUGBANK | Half-life | 14.0 | h | 14 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 170.0 | mg/kg | 170.0 | mg/kg | Intraperitoneal, IP; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 160.0 | mg/kg | 160.0 | mg/kg | Intraperitoneal, IP; mouse; | DRUGBANK | Toxicity LD50 | 400.0 | mg/kg | 400.0 | mg/kg | subcutaneous injection, SC; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 240.0 | mg/kg | 240.0 | mg/kg | subcutaneous injection, SC; mouse; | DRUGBANK | Toxicity LD50 | 255.0 | mg/kg | 255.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 55.0 | mg/kg | 55.0 | mg/kg | intravenous injection, IV; mouse; | T3DB |
| Eliminate Route | 0.64 | % | 0.64 | % | Urinary excretion; intravenous injection, IV; Unchanged drug; | DRUGBANK |
| Protein Binding | 93.0 | % | 93 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.0 | 0 | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR | |||
| Max dose for infants | 0.0 | 0 | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR | |||
| Max dose for children | 1.1 | mg/kg/dose | 1.1 | mg/kg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;Rectal Administration; | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR |
| Max dose for children | 25.0 | mg/dose | 25 | mg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;Rectal Administration; | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR |
| Max dose for children | 0.0 | 0 | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR | |||
| Max dose for adolescents | 1.1 | mg/kg/dose | 1.1 | mg/kg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;Rectal Administration; | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR |
| Max dose for adolescents | 25.0 | mg/dose | 25 | mg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;Rectal Administration; | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR |
| Max dose for adults | 50.0 | mg/dose | 50 | mg/dose | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR | |
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR | |
| Max dose for geriatric | 50.0 | mg/dose | 50 | mg/dose | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR | |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | Promethazine Hydrochloride Syrup | promethazine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1