Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01068 ...
Drug Name Clonazepam
Molecular Weight 315.711
Molecular Formula C15H10ClN3O3
CAS Number 1622-61-3
SMILES [O-][N+](=O)C1=CC2=C(NC(=O)CN=C2C2=CC=CC=C2Cl)C=C1
External Links
DRUGBANK DB01068
T3DB T3D2973
PubChem Compound 2802
PDR 3064
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.41 - 2.41 - HANSCH,C ET AL. (1995)
Melting Point 239.0 ℃ 238-240 ℃ Kariss, J. and Newmark, H.L.; US. Patents 3,116,203; December 31, 1963; and 3,123,529; March 3, 1964; both assigned to Hoffmann-LaRoche, Inc. Keller, O., Steiger, N. and Sternbach, L.H.; U S . Patents 3,121,114; February 11, 1964; and 3,203990; August 31, 1965; both assigned to Hoffmann-LaRoche, Inc. Focella, A. and Rachlin, A.I.; U.S. Patent 3,335,181; August 8, 1967; assigned to Hoffmann- LaRoche. Inc.
Water Solubility 100.0 mg/L 100 mg/L MERCK INDEX 1996)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % ~100 % Tablet, PO, oral; DRUGBANK
Bioavailability 90.0 % ~90 % Tablet, PO, oral; DRUGBANK
Bioavailability 98.0 % 98±31 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 17.0 ng/ml 17±5.4 ng/ml Tablet, PO, oral; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 16.0 ng/ml 3-29 ng/ml intravenous injection, IV; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.5 h 1-4 h Tablet, PO, oral; DRUGBANK
T Max 2.5 h 2.5±1.3 h Tablet, PO, oral; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 3.3 L/h ~55 ml/min gaining weight ↓ ; DRUGBANK
Clearance 0.0930 L/h/kg 1.55±0.28 ml/min/kg apparent clearance; hydrolysis; The Pharmacological Basis of Therapeutics
Clearance 0.0528 L/h/kg 0.88 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 3.0 L/kg ~3 L/kg Apparent volume of distribution; DRUGBANK
Volume of Distribution 3.2 L/kg 3.2±1.1 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 2.9 L/kg 2.9 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 35.0 h ~30-40 h elimination half-life; dose → ; DRUGBANK
Half-life 23.0 h 23±5 h The Pharmacological Basis of Therapeutics
Half-life 38.0 h 38 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 4000.0 mg/kg 4000.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 4000.0 mg/kg 4000.0 mg/kg PO, oral; adults; Rattus, Rat; DRUGBANK
Toxicity LD50 2000.0 mg/kg 2000.0 mg/kg PO, oral; rabbit; DRUGBANK
Toxicity LD50 15000.0 mg/kg >15000 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 60.0 % ~50-70 % Urinary excretion; DRUGBANK
Eliminate Route 2.0 % <2 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 84.0 % 82-86 % plasma proteins; DRUGBANK
Protein Binding 86.0 % 86±0.5 % Neonates ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 0.15 mg/kg/day 0.15 mg/kg/day PO, oral Klonopin clonazepam PDR
Max dose for children 0.15 mg/kg/day 0.15 mg/kg/day PO, oral Klonopin clonazepam PDR
Max dose for adolescents 20.0 mg/day 20 mg/day PO, oral Klonopin clonazepam PDR
Max dose for adolescents 0.15 mg/kg/day 0.15 mg/kg/day PO, oral Klonopin clonazepam PDR
Max dose for adults 20.0 mg/day 20 mg/day PO, oral Klonopin clonazepam PDR
Max dose for geriatric 20.0 mg/day 20 mg/day PO, oral Klonopin clonazepam PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1