Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01062 ...
Drug Name Oxybutynin
Molecular Weight 357.4864
Molecular Formula C22H31NO3
CAS Number 5633-20-5
SMILES CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C1=CC=CC=C1
External Links
DRUGBANK DB01062
PubChem Compound 4634
PDR 1429
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.3 - 4.3 - http://www.hmdb.ca/metabolites/HMDB0015195
Melting Point 123.0 ℃ 122-124 ℃ https://www.chemicalbook.com/ChemicalProductProperty_US_CB0178112.aspx
Water Solubility 50000.0 mg/L 50 mg/ml https://www.chemicalbook.com/ChemicalProductProperty_US_CB0178112.aspx
pKa 8.04 - 8.04 - https://www.chemicalbook.com/ChemicalProductProperty_US_CB2767266.aspx
Log S -4.6 - -4.6 - http://www.hmdb.ca/metabolites/HMDB0015195

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 16.0 ng.h/ml 16.0 ng.h/ml PO, oral; DRUGBANK
Bioavailability 6.0 % 6 % PO, oral; DRUGBANK
Bioavailability 6.3 % 1.6-10.9 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 8.2 ng/ml 8.2 ng/ml PO, oral; DRUGBANK
C Max 69.7 ng/ml 41-98.4 ng/ml PO, oral; Active metabolite; DRUGBANK
C Max 12.4 ng/ml 12.4±4.1 ng/ml PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
C Max 4.2 ng/ml 4.2±1.6 ng/ml PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
T Max 1.0 h 1 h PO, oral; DRUGBANK
T Max 5.0 h 5.0±4.2 h PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 5.2 h 5.2±3.7 h PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
Clearance 0.49 L/h/kg 8.1±2.3 ml/min/kg intravenous injection, IV; normal,healthy; adults; The Pharmacological Basis of Therapeutics
Clearance 0.31 L/h/kg 5.1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 193.0 L 193.0 L DRUGBANK
Volume of Distribution 1.3 L/kg 1.3±0.4 L/kg intravenous injection, IV; normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.85 L/kg 0.85 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.0 h ~2 h elimination half-life; DRUGBANK
Half-life 5.0 h 5 h elimination half-life; Elderly; DRUGBANK
Half-life 1.9 h 1.9±0.35 h intravenous injection, IV; normal,healthy;  Female, women; The Pharmacological Basis of Therapeutics
Half-life 5.3 h 5.3 h intravenous injection, IV; The Pharmacological Basis of Therapeutics
Half-life 9.0 h 9±2 h PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
Half-life 14.0 h 14±3 h PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
Half-life 4.0 h 4.0±1.4 h immediate release formulation; The Pharmacological Basis of Therapeutics
Half-life 8.3 h 8.3±2.5 h extended release formulation; The Pharmacological Basis of Therapeutics
Half-life 7.2 h 7.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 460.0 mg/kg 460.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 0.10 % <0.1 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion;  Female, women; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 97.0 % >97 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 15.0 mg/day 15 mg/day PO, oral Ditropan XL oxybutynin chloride PDR
Max dose for children 20.0 mg/day 20 mg/day PO, oral Ditropan XL oxybutynin chloride PDR
Max dose for children 15.0 mg/day 15 mg/day PO, oral Ditropan XL oxybutynin chloride PDR
Max dose for adolescents 20.0 mg/day 20 mg/day PO, oral Ditropan XL oxybutynin chloride PDR
Max dose for adolescents 17.5 mg/day 17.5 mg/day PO, oral Ditropan XL oxybutynin chloride PDR
Max dose for adults 20.0 mg/day 20 mg/day PO, oral Ditropan XL oxybutynin chloride PDR
Max dose for adults 30.0 mg/day 30 mg/day PO, oral Ditropan XL oxybutynin chloride PDR
Max dose for geriatric 20.0 mg/day 20 mg/day PO, oral Ditropan XL oxybutynin chloride PDR
Max dose for geriatric 30.0 mg/day 30 mg/day PO, oral Ditropan XL oxybutynin chloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1