Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01060 ...
Drug Name Amoxicillin
Molecular Weight 365.404
Molecular Formula C16H19N3O5S
CAS Number 26787-78-0
SMILES [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=O
External Links
DRUGBANK DB01060
PubChem Compound 33613
PDR 1338
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -6.1 - -6.1 - ADME Research, USCD
Log P 0.87 - 0.87 - SANGSTER (1994)
Boiling Point 743.2 ℃ 743.2 ℃ ChemSpider
Melting Point 194.0 ℃ 194 ℃ ChemSpider

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 27290.0 ng.h/ml 27.29±4.72 mg.h/l PO, oral; DRUGBANK
AUC 55040.0 ng.h/ml 55.04±12.68 mg.h/l PO, oral; DRUGBANK
Bioavailability 60.0 % ~60 % DRUGBANK
Bioavailability 93.0 % 93±10 % PO, oral; The Pharmacological Basis of Therapeutics
Bioavailability 50.0 % 50 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 3930.0 ng/ml 3.93±1.13 mg/L PO, oral; DRUGBANK
C Max 11210.0 ng/ml 11.21±3.42 mg/L PO, oral; DRUGBANK
C Max 46000.0 ng/ml 46±12 mcg/ml intravenous injection, IV; Elderly; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 5000.0 ng/ml 5.0 mcg/ml Oral single dose; adults; The Pharmacological Basis of Therapeutics
T Max 1.3 h 1.31±0.33 h PO, oral; DRUGBANK
T Max 1.5 h 1.52±0.40 h PO, oral; DRUGBANK
T Max 1.5 h 1-2 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 21.3 L/h 21.3 L/h Average clearance; DRUGBANK
Clearance 0.16 L/h/kg 2.6±0.4 ml/min/kg Children → ;Elderly ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;normal renal function → ; The Pharmacological Basis of Therapeutics
Clearance 0.20 L/h/kg 3.3 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 22.7 L 22.7 L Total volume of distribution; DRUGBANK
Volume of Distribution 0.21 L/kg 0.21±0.03 L/kg Elderly → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.25 L/kg 0.25 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.0 h 61.3 min DRUGBANK
Half-life 1.7 h 1.7±0.3 h Children → ;RD, renal impairment, Renal disease，including uremia ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 1.1 h 1.1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 74.0 % 70-78 % Urinary excretion; DRUGBANK
Eliminate Route 86.0 % 86±8 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 17.0 % ~17 % DRUGBANK
Protein Binding 18.0 % 18 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 30.0 mg/kg/day 30 mg/kg/day PO, oral Moxatag amoxicillin PDR
Max dose for neonates 75.0 mg/kg/day 75 mg/kg/day PO, oral Moxatag amoxicillin PDR
Max dose for infants 45.0 mg/kg/day 45 mg/kg/day PO, oral Moxatag amoxicillin PDR
Max dose for infants 90.0 mg/kg/day 90 mg/kg/day PO, oral Moxatag amoxicillin PDR
Max dose for infants 30.0 mg/kg/day 30 mg/kg/day PO, oral Moxatag amoxicillin PDR
Max dose for infants 75.0 mg/kg/day 75 mg/kg/day PO, oral Moxatag amoxicillin PDR
Max dose for children 45.0 mg/kg/day 45 mg/kg/day PO, oral Moxatag amoxicillin PDR
Max dose for children 100.0 mg/kg/day 100 mg/kg/day PO, oral Moxatag amoxicillin PDR
Max dose for children 4000.0 mg/day 4 g/day PO, oral Moxatag amoxicillin PDR
Max dose for adolescents 1750.0 mg/day 1750 mg/day PO, oral Moxatag amoxicillin PDR
Max dose for adolescents 4000.0 mg/day 4 g/day PO, oral Moxatag amoxicillin PDR
Max dose for adults 1750.0 mg/day 1750 mg/day PO, oral Moxatag amoxicillin PDR
Max dose for adults 3000.0 mg/day 3 g/day PO, oral Moxatag amoxicillin PDR
Max dose for geriatric 1750.0 mg/day 1750 mg/day PO, oral Moxatag amoxicillin PDR
Max dose for geriatric 3000.0 mg/day 3 g/day PO, oral Moxatag amoxicillin PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1