Drug ID | DDPD01060 |
|
Drug Name | Amoxicillin | |
Molecular Weight | 365.404 | |
Molecular Formula | C16H19N3O5S | |
CAS Number | 26787-78-0 | |
SMILES | [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=O | |
External Links | ||
DRUGBANK | DB01060 | |
PubChem Compound | 33613 | |
PDR | 1338 | |
Drugs.com | Drugs.com Drug Page |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
---|---|---|---|---|---|
Caco-2 Permeability | -6.1 | - | -6.1 | - | ADME Research, USCD |
Log P | 0.87 | - | 0.87 | - | SANGSTER (1994) |
Boiling Point | 743.2 | ℃ | 743.2 | ℃ | ChemSpider |
Melting Point | 194.0 | ℃ | 194 | ℃ | ChemSpider |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
---|---|---|---|---|---|---|---|
AUC | 27290.0 | ng.h/ml | 27.29±4.72 | mg.h/l | PO, oral; | DRUGBANK | |
AUC | 55040.0 | ng.h/ml | 55.04±12.68 | mg.h/l | PO, oral; | DRUGBANK | |
Bioavailability | 60.0 | % | ~60 | % | DRUGBANK | ||
Bioavailability | 93.0 | % | 93±10 | % | PO, oral; | The Pharmacological Basis of Therapeutics | |
Bioavailability | 50.0 | % | 50 | % | PO, oral; | The Pharmacological Basis of Therapeutics | |
C Max | 3930.0 | ng/ml | 3.93±1.13 | mg/L | PO, oral; | DRUGBANK | |
C Max | 11210.0 | ng/ml | 11.21±3.42 | mg/L | PO, oral; | DRUGBANK | |
C Max | 46000.0 | ng/ml | 46±12 | mcg/ml | intravenous injection, IV; Elderly; normal,healthy; | The Pharmacological Basis of Therapeutics | |
C Max | 5000.0 | ng/ml | 5.0 | mcg/ml | Oral single dose; adults; | The Pharmacological Basis of Therapeutics | |
T Max | 1.3 | h | 1.31±0.33 | h | PO, oral; | DRUGBANK | |
T Max | 1.5 | h | 1.52±0.40 | h | PO, oral; | DRUGBANK | |
T Max | 1.5 | h | 1-2 | h | PO, oral; | The Pharmacological Basis of Therapeutics | |
Clearance | 21.3 | L/h | 21.3 | L/h | Average clearance; | DRUGBANK | |
Clearance | 0.16 | L/h/kg | 2.6±0.4 | ml/min/kg | Children → ;Elderly ↓ ;RD, renal impairment, Renal disease,including uremia ↓ ;normal renal function → ; | The Pharmacological Basis of Therapeutics | |
Clearance | 0.20 | L/h/kg | 3.3 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
Volume of Distribution | 22.7 | L | 22.7 | L | Total volume of distribution; | DRUGBANK | |
Volume of Distribution | 0.21 | L/kg | 0.21±0.03 | L/kg | Elderly → ;RD, renal impairment, Renal disease,including uremia → ; | The Pharmacological Basis of Therapeutics | |
Volume of Distribution | 0.25 | L/kg | 0.25 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
Half-life | 1.0 | h | 61.3 | min | DRUGBANK | ||
Half-life | 1.7 | h | 1.7±0.3 | h | Children → ;RD, renal impairment, Renal disease,including uremia ↑ ;Age ↑ ; | The Pharmacological Basis of Therapeutics | |
Half-life | 1.1 | h | 1.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
Eliminate Route | 74.0 | % | 70-78 | % | Urinary excretion; | DRUGBANK | |
Eliminate Route | 86.0 | % | 86±8 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics | |
Protein Binding | 17.0 | % | ~17 | % | DRUGBANK | ||
Protein Binding | 18.0 | % | 18 | % | The Pharmacological Basis of Therapeutics |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
---|---|---|---|---|---|---|---|---|
Max dose for neonates | 30.0 | mg/kg/day | 30 | mg/kg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for neonates | 75.0 | mg/kg/day | 75 | mg/kg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for infants | 45.0 | mg/kg/day | 45 | mg/kg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for infants | 90.0 | mg/kg/day | 90 | mg/kg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for infants | 30.0 | mg/kg/day | 30 | mg/kg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for infants | 75.0 | mg/kg/day | 75 | mg/kg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for children | 45.0 | mg/kg/day | 45 | mg/kg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for children | 100.0 | mg/kg/day | 100 | mg/kg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for children | 4000.0 | mg/day | 4 | g/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for adolescents | 1750.0 | mg/day | 1750 | mg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for adolescents | 4000.0 | mg/day | 4 | g/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for adults | 1750.0 | mg/day | 1750 | mg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for adults | 3000.0 | mg/day | 3 | g/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for geriatric | 1750.0 | mg/day | 1750 | mg/day | PO, oral | Moxatag | amoxicillin | PDR |
Max dose for geriatric | 3000.0 | mg/day | 3 | g/day | PO, oral | Moxatag | amoxicillin | PDR |