DETAILS

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	2.5	-	2.5	-	DRUGBANK
Melting Point	136.0	℃	136	℃	PhysProp
Water Solubility	400.0	mg/L	400	mg/L	MERCK INDEX 1996)

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
Absorption	80.0	%	80	%			DRUGBANK
C Max	3550.0	ng/ml	0.8-6.3	mcg/ml	Oral single dose;		The Pharmacological Basis of Therapeutics
T Max	1.7	h	1.5-1.8	h	Oral single dose;		The Pharmacological Basis of Therapeutics
Clearance	28.0	L/h/kg	467.0	ml/min/kg	apparent clearance;		The Pharmacological Basis of Therapeutics
Clearance	8.4	L/h/kg	57-222	ml/min/kg	apparent clearance;	hepatopathy，LD ↓ ;	The Pharmacological Basis of Therapeutics
Volume of Distribution	9.6	L/kg	9.55±2.86	L/kg			The Pharmacological Basis of Therapeutics
Half-life	1.2	h	0.8-1.5	h			DRUGBANK
Half-life	1.2	h	0.8-1.5	h	Male, men; Female, women; schistosomiasis;		The Pharmacological Basis of Therapeutics
Half-life	2.4	h	1.7-3.0	h	Male, men; Female, women; schistosomiasis;	chronic liver disease ↑ ;	The Pharmacological Basis of Therapeutics
Eliminate Route	0	%	~0	%	Urinary excretion; schistosomiasis; human, homo sapiens; Unchanged drug;		The Pharmacological Basis of Therapeutics
Protein Binding	82.5	%	80-85	%			DRUGBANK
Protein Binding	82.5	%	80-85	%	schistosomiasis; human, homo sapiens;		The Pharmacological Basis of Therapeutics

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for children	75.0	mg/kg/day	75	mg/kg/day	PO, oral	Biltricide	praziquantel	PDR
Max dose for adolescents	75.0	mg/kg/day	75	mg/kg/day	PO, oral	Biltricide	praziquantel	PDR
Max dose for adults	75.0	mg/kg/day	75	mg/kg/day	PO, oral	Biltricide	praziquantel	PDR
Max dose for geriatric	75.0	mg/kg/day	75	mg/kg/day	PO, oral	Biltricide	praziquantel	PDR

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1