Basic Information

Drug ID DDPD01056 ...
Drug Name Tocainide
Molecular Weight 192.2575
Molecular Formula C11H16N2O
CAS Number 41708-72-9
SMILES CC(N)C(=O)NC1=C(C)C=CC=C1C
External Links
DRUGBANK DB01056
PubChem Compound 38945
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.76 - 0.76 - SANGSTER (1993)
Melting Point 256.0 246-266 PhysProp
Water Solubility 10700.0 mg/L 10700 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 100.0 % ~100 % PO, oral; food; food → ; DRUGBANK
Clearance 0.13 L/h/kg 2.2 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.8 L/kg 1.8 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 15.0 h ~15 h elimination half-life; patients; DRUGBANK
Half-life 35.0 h 35 h severe renal function; DRUGBANK
Half-life 12.0 h 12 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 800.0 mg/kg ~800 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 1000.0 mg/kg 1000.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 230.0 mg/kg 230.0 mg/kg PO, oral; guinea pigs; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1