Basic Information

Drug ID DDPD01054 ...
Drug Name Nitrendipine
Molecular Weight 360.3612
Molecular Formula C18H20N2O6
CAS Number 39562-70-4
SMILES CCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC
External Links
DRUGBANK DB01054
PubChem Compound 4507

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -4.77 - -4.77 - ADME Research, USCD
Log P 2.88 - 2.88 - MASUMATO,K ET AL. (1995)
Melting Point 158.0 156-160 DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 1.5 L/h/kg 25 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 6.1 L/kg 6.1 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 8.2 h 8.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 99.0 % >99 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1