Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01053 ...
Drug Name Benzylpenicillin
Molecular Weight 334.39
Molecular Formula C16H18N2O4S
CAS Number 61-33-6
SMILES [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)CC1=CC=CC=C1)C(O)=O
External Links
DRUGBANK DB01053
PubChem Compound 5904
PDR 1150

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.83 - 1.83 - HANSCH,C ET AL. (1995)
Melting Point 215.5 ℃ 214-217 ℃ DRUGBANK
Water Solubility 210.0 mg/L 210 mg/L DRUGBANK
pKa 2.74 - 2.74 - MERCK INDEX (1996)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 22.5 % 15-30 % PO, oral; normal,healthy; fasting; DRUGBANK
Bioavailability 30.0 % 30.0 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 740.0 ng/ml 0.28-1.2 mcg/ml Liquid; The Pharmacological Basis of Therapeutics
C Max 12000.0 ng/ml 12.0 mcg/ml IM,intramuscular injection; Derivative; The Pharmacological Basis of Therapeutics
C Max 940.0 ng/ml 0.94 mcg/ml IM,intramuscular injection; Derivative; The Pharmacological Basis of Therapeutics
C Max 160.0 ng/ml 0.16 mcg/ml IM,intramuscular injection; Derivative; The Pharmacological Basis of Therapeutics
T Max 0.75 h 0.5-1 h Liquid; The Pharmacological Basis of Therapeutics
T Max 0.50 h 0.5 h IM,intramuscular injection; Derivative; The Pharmacological Basis of Therapeutics
T Max 2.0 h 1-3 h IM,intramuscular injection; Derivative; The Pharmacological Basis of Therapeutics
T Max 18.0 h 12-24 h IM,intramuscular injection; Derivative; The Pharmacological Basis of Therapeutics
Metabolic 16.0 % 16 % Inactive metabolite; DRUGBANK
Clearance 33.6 L/h 560.0 ml/min normal,healthy; human, homo sapiens; DRUGBANK
Clearance 0.42 L/h/kg 5-9 ml/min/kg RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.60 L/kg 0.53–0.67 L/kg normal renal function; adults; DRUGBANK
Volume of Distribution 0.33 L/kg 0.33 L/kg The Pharmacological Basis of Therapeutics
Half-life 0.65 h 0.4-0.9 h adults; normal renal function; DRUGBANK
Half-life 0.50 h 0.5±0.1 h RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 3.0 h ~3 h terminal half-life; RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 8900.0 mg/kg 8900.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 79.0 % 79 % Urinary excretion; adults; Adolescents; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 56.5 % 45-68 % DRUGBANK
Protein Binding 60.0 % 60(48-68) % adults; Adolescents; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 100000.0 units/kg/day 100000 units/kg/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for neonates 450000.0 units/kg/day 450000 units/kg/day IM,intramuscular injection;intravenous injection, IV; Penicillin G Potassium penicillin G potassium PDR
Max dose for neonates 150000.0 units/kg/day 150000 units/kg/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for neonates 500000.0 units/kg/day 500000 units/kg/day IM,intramuscular injection;intravenous injection, IV; Penicillin G Potassium penicillin G potassium PDR
Max dose for infants 300000.0 units/kg/day 300000 units/kg/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for infants 400000.0 units/kg/day 400000 units/kg/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for children 300000.0 units/kg/day 300000 units/kg/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for children 24000000.0 units/kg/day 24000000 units/kg/day Penicillin G Potassium penicillin G potassium PDR
Max dose for children 400000.0 units/kg/day 400000 units/kg/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for adolescents 300000.0 units/kg/day 300000 units/kg/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for adolescents 24000000.0 units/kg/day 24000000 units/kg/day Penicillin G Potassium penicillin G potassium PDR
Max dose for adolescents 400000.0 units/kg/day 400000 units/kg/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for adults 80000000.0 units/day 80000000 units/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for geriatric 80000000.0 units/day 80000000 units/day intravenous injection, IV;IM,intramuscular injection; Penicillin G Potassium penicillin G potassium PDR
Max dose for neonates 50000.0 units/kg/day 50000 units/kg/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR
Max dose for infants 50000.0 units/kg/day 50000 units/kg/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR
Max dose for infants 6000000.0 units/kg/day 6000000 units/kg/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR
Max dose for children 50000.0 units/kg/day 50000 units/kg/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR
Max dose for children 2400000.0 units/day 2400000 units/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR
Max dose for adolescents 50000.0 units/kg/day 50000 units/kg/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR
Max dose for adolescents 2400000.0 units/day 2400000 units/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR
Max dose for adults 2400000.0 units/day 2400000 units/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR
Max dose for geriatric 2400000.0 units/day 2400000 units/day IM,intramuscular injection Bicillin L-A penicillin G benzathine PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1