Basic Information
| Drug ID | DDPD01048 |
|
| Drug Name | Abacavir | |
| Molecular Weight | 286.3323 | |
| Molecular Formula | C14H18N6O | |
| CAS Number | 136470-78-5 | |
| SMILES | NC1=NC2=C(N=CN2[C@@H]2C[C@H](CO)C=C2)C(NC2CC2)=N1 | |
| External Links | ||
| DRUGBANK | DB01048 | |
| PubChem Compound | 441300 | |
| PDR | 609 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.2 | - | 1.2 | - | FDA label |
| Melting Point | 165.0 | ℃ | 165 | ℃ | DRUGBANK |
| Water Solubility | 77000.0 | mg/L | 77 | mg/ml | FDA label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.80 | L/h/kg | 0.80±0.24 | l/h/kg | intravenous injection, IV; Single dose; AIDS,HIV; adults; | DRUGBANK | Clearance | 0.78 | L/h/kg | 13 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.86 | L/kg | 0.86±0.15 | L/kg | intravenous injection, IV; | DRUGBANK | Volume of Distribution | 0.84 | L/kg | 0.84 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.5 | h | 1.54±0.63 | h | DRUGBANK | Half-life | 1.0 | h | 1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 99.0 | % | 99 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 16.0 | % | 16 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 50.0 | % | ~50 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 16.0 | mg/kg/day | 16 | mg/kg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for infants | 20.0 | mg/kg/day | 20 | mg/kg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for children | 16.0 | mg/kg/day | 16 | mg/kg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for children | 600.0 | mg/day | 600 | mg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for children | 20.0 | mg/kg/day | 20 | mg/kg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for children | 600.0 | mg/day | 600 | mg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for adolescents | 16.0 | mg/kg/day | 16 | mg/kg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for adolescents | 20.0 | mg/kg/day | 20 | mg/kg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral | Ziagen | abacavir | PDR |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | PO, oral | Ziagen | abacavir | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1