Basic Information
| Drug ID | DDPD01045 |
|
| Drug Name | Rifampicin | |
| Molecular Weight | 822.9402 | |
| Molecular Formula | C43H58N4O12 | |
| CAS Number | 13292-46-1 | |
| SMILES | CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(O)C(\C=N\N4CCN(C)CC4)=C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(O)=C2C(O)=C3C | |
| External Links | ||
| DRUGBANK | DB01045 | |
| T3DB | T3D2969 | |
| PubChem Compound | 5381226 | |
| PDR | 1036 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.7 | - | 2.7 | - | DRUGBANK |
| Melting Point | 183.0 | ℃ | 183 | ℃ | DRUGBANK |
| Water Solubility | 1400.0 | mg/L | 1400 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 1.7 | - | 1.7 | - | SANGSTER (2004) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 6500.0 | ng/ml | 6.5±3.5 | mcg/ml | PO, oral; tuberculosis; | The Pharmacological Basis of Therapeutics | |
| T Max | 2.0 | h | 1-3 | h | PO, oral; tuberculosis; | The Pharmacological Basis of Therapeutics | |
| Clearance | 0.19 | L/h/kg | 0.19±0.06 | l/h/kg | intravenous injection, IV; | DRUGBANK | Clearance | 0.14 | L/h/kg | 0.14±0.03 | l/h/kg | intravenous injection, IV; | DRUGBANK | Clearance | 0.21 | L/h/kg | 3.5±1.6 | ml/min/kg | Neonates ↑ ;Elderly → ;RD, renal impairment, Renal disease，including uremia ↓ ; | The Pharmacological Basis of Therapeutics |
| Volume of Distribution | 0.97 | L/kg | 0.97±0.36 | L/kg | Neonates ↑ ;Elderly → ; | The Pharmacological Basis of Therapeutics | |
| Half-life | 3.4 | h | 3.35±0.66 | h | DRUGBANK | Half-life | 3.5 | h | 3.5±0.8 | h | Children → ;Hepatitis, Hep ↑ ;Hepatic cirrhosis, cirr ↑ ;acute viral hepatitis AVH ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ;Age → ; | The Pharmacological Basis of Therapeutics |
| Toxicity LD50 | 1570.0 | mg/kg | 1570.0 | mg/kg | Rattus, Rat; | DRUGBANK | Toxicity LD50 | 1570.0 | mg/kg | 1570.0 | mg/kg | Rattus, Rat; | T3DB |
| Eliminate Route | 30.0 | % | <30 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 7.0 | % | 7±3 | % | Urinary excretion; Unchanged drug; | Neonates ↑ ; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 89.0 | % | 89 | % | DRUGBANK | Protein Binding | 75.0 | % | 60-90 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 10.0 | mg/kg/day | 10 | mg/kg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for neonates | 20.0 | mg/kg/day | 20 | mg/kg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for infants | 20.0 | mg/kg/day | 20 | mg/kg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for children | 20.0 | mg/kg/day | 20 | mg/kg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for children | 600.0 | mg/day | 600 | mg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for children | 1200.0 | mg/day | 1200 | mg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for adolescents | 20.0 | mg/kg/day | 20 | mg/kg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for adolescents | 1200.0 | mg/day | 1200 | mg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for adults | 10.0 | mg/kg/day | 10 | mg/kg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for adults | 1200.0 | mg/day | 1200 | mg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for geriatric | 10.0 | mg/kg/day | 10 | mg/kg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
| Max dose for geriatric | 1200.0 | mg/day | 1200 | mg/day | intravenous injection, IV;PO, oral; | Rifadin | rifampin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1