Basic Information
| Drug ID | DDPD01044 |
|
| Drug Name | Gatifloxacin | |
| Molecular Weight | 375.3941 | |
| Molecular Formula | C19H22FN3O4 | |
| CAS Number | 112811-59-3 | |
| SMILES | COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNC(C)C1)C1CC1 | |
| External Links | ||
| DRUGBANK | DB01044 | |
| T3DB | T3D2968 | |
| PubChem Compound | 5379 | |
| PDR | 2309 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.6 | - | 2.6 | - | DRUGBANK |
| Melting Point | 183.5 | ℃ | 182-185 | ℃ | DRUGBANK |
| Water Solubility | 60000.0 | mg/L | 60 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 96.0 | % | 96 | % | PO, oral; | DRUGBANK |
| Metabolic | 1.0 | % | <1 | % | Urinary excretion; | DRUGBANK |
| Clearance | 0.17 | L/h/kg | 2.8 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.7 | L/kg | 1.7 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 10.5 | h | 7-14 | h | DRUGBANK | Half-life | 10.0 | h | 10 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 20.0 | % | 20 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 8.0 | drop/day | 8 | drop/day | ophthalmic administration | Zymaxid | gatifloxacin | PDR |
| Max dose for infants | 8.0 | drop/day | 8 | drop/day | ophthalmic administration | Zymaxid | gatifloxacin | PDR |
| Max dose for children | 8.0 | drop/day | 8 | drop/day | ophthalmic administration | Zymaxid | gatifloxacin | PDR |
| Max dose for adolescents | 8.0 | drop/day | 8 | drop/day | ophthalmic administration | Zymaxid | gatifloxacin | PDR |
| Max dose for adults | 8.0 | drop/day | 8 | drop/day | ophthalmic administration | Zymaxid | gatifloxacin | PDR |
| Max dose for geriatric | 8.0 | drop/day | 8 | drop/day | ophthalmic administration | Zymaxid | gatifloxacin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1