Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01042 ...
Drug Name Melphalan
Molecular Weight 305.2
Molecular Formula C13H18Cl2N2O2
CAS Number 148-82-3
SMILES N[C@@H](CC1=CC=C(C=C1)N(CCCl)CCCl)C(O)=O
External Links
DRUGBANK DB01042
T3DB T3D4702
PubChem Compound 460612
PDR 2833
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.52 - -0.52 - SANGSTER,J (1994) @pH=7.4
Melting Point 182.5 ℃ 182.5 ℃ PhysProp
Water Solubility 1000.0 mg/L <0.1 g/100ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 57.0 % 25-89 % DRUGBANK
Bioavailability 71.0 % 71±23 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 310.0 ng/ml 0.31±0.15 mcg/ml PO, oral; tumor; The Pharmacological Basis of Therapeutics
C Max 1300.0 ng/ml 1.3±0.95 mcg/ml intravenous injection, IV; tumor; The Pharmacological Basis of Therapeutics
T Max 0.75 h 0.75±0.24 h PO, oral; tumor; The Pharmacological Basis of Therapeutics
Clearance 0.31 L/h/kg 5.2±2.9 ml/min/kg Children → ; The Pharmacological Basis of Therapeutics
Clearance 0.42 L/h/kg 7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.50 L/kg 0.5 L/kg DRUGBANK
Volume of Distribution 0.45 L/kg 0.45±0.15 L/kg Children → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.48 L/kg 0.48 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.5 h 1.5±0.83 h DRUGBANK
Half-life 1.4 h 1.4±0.2 h Children → ; The Pharmacological Basis of Therapeutics
Half-life 1.0 h 1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 11.2 mg/kg 11.2 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 11.2 mg/kg 11.2 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 10.0 % 10±4.5 % Urinary excretion; patients; DRUGBANK
Eliminate Route 12.0 % 12±7 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 75.0 % 60-90 % DRUGBANK
Protein Binding 90.0 % 90±5 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 100.0 mg/m2 100 mg/m2 intravenous injection, IV Alkeran for Injection melphalan hydrochloride PDR
Max dose for adults 200.0 mg/m2 200 mg/m2 intravenous injection, IV Alkeran for Injection melphalan hydrochloride PDR
Max dose for adults 16.0 mg/m2 16 mg/m2 intravenous injection, IV; nan Alkeran for Injection melphalan hydrochloride PDR
Max dose for geriatric 100.0 mg/m2 100 mg/m2 intravenous injection, IV Alkeran for Injection melphalan hydrochloride PDR
Max dose for geriatric 200.0 mg/m2 200 mg/m2 intravenous injection, IV Alkeran for Injection melphalan hydrochloride PDR
Max dose for geriatric 16.0 mg/m2 16 mg/m2 intravenous injection, IV Alkeran for Injection melphalan hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1