Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01039 ...
Drug Name Fenofibrate
Molecular Weight 360.831
Molecular Formula C20H21ClO4
CAS Number 49562-28-9
SMILES CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1
External Links
DRUGBANK DB01039
T3DB T3D4775
PubChem Compound 3339
PDR 1045
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 5.2 - 5.2 - Wei et al, 2017
Melting Point 80.5 ℃ 79-82 ℃ FDA Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 7750.0 ng/ml 6-9.5 mg/L PO, oral; normal,healthy; fasting; DRUGBANK
C Max 8600.0 ng/ml 8.6±0.9 mcg/ml Tablet, PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
C Max 10800.0 ng/ml 10.8±0.6 mcg/ml Capsule, PO, Oral; Drug form; The Pharmacological Basis of Therapeutics
T Max 5.0 h 4-6 h PO, oral; normal,healthy; fasting; DRUGBANK
T Max 7.0 h 6-8 h Tablet, PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 5.0 h 4-6 h Capsule, PO, Oral; Drug form; The Pharmacological Basis of Therapeutics
Clearance 1.1 L/h 1.1 L/h PO, oral; young; adults; DRUGBANK
Clearance 1.2 L/h 1.2 L/h PO, oral; Elderly; DRUGBANK
Clearance 0.0270 L/h/kg 0.45 ml/min/kg apparent clearance; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.89 L/kg 0.89 L/kg DRUGBANK
Volume of Distribution 0.89 L/kg 0.89 L/kg Apparent volume of distribution; The Pharmacological Basis of Therapeutics
Half-life 23.0 h 23 h DRUGBANK
Half-life 23.0 h 19-27 h normal,healthy; DRUGBANK
Half-life 143.0 h 143 h patients; DRUGBANK
Half-life 23.5 h 20-27 h RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 2000.0 mg/kg >2 g/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1600.0 mg/kg 1600.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 1600.0 mg/kg 1600.0 mg/kg PO, oral; mouse; T3DB
Toxicity TDLo 9.0 mg/kg 9.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 15.0 % 5-25 % Faeces excretion; DRUGBANK
Eliminate Route 74.0 % 60-88 % Urinary excretion; DRUGBANK
Eliminate Route 5.1 % 0.1-10 % Urinary excretion; PO, oral; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 99.0 % 99 % DRUGBANK
Protein Binding 99.0 % >99 % Active metabolite; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 145.0 mg/day 145 mg/day Tablet,PO，oral Triglide fenofibrate PDR
Max dose for adults 160.0 mg/day 160 mg/day Tablet,PO，oral Triglide fenofibrate PDR
Max dose for adults 200.0 mg/day 200 mg/day Capsule, PO, Oral Triglide fenofibrate PDR
Max dose for adults 90.0 mg/day 90 mg/day Capsule, PO, Oral Triglide fenofibrate PDR
Max dose for adults 150.0 mg/day 150 mg/day Capsule, PO, Oral Triglide fenofibrate PDR
Max dose for geriatric 145.0 mg/day 145 mg/day Tablet,PO，oral Triglide fenofibrate PDR
Max dose for geriatric 160.0 mg/day 160 mg/day Tablet,PO，oral Triglide fenofibrate PDR
Max dose for geriatric 200.0 mg/day 200 mg/day Capsule, PO, Oral Triglide fenofibrate PDR
Max dose for geriatric 90.0 mg/day 90 mg/day Capsule, PO, Oral Triglide fenofibrate PDR
Max dose for geriatric 150.0 mg/day 150 mg/day Capsule, PO, Oral Triglide fenofibrate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1