Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01037 ...
Drug Name Selegiline
Molecular Weight 187.286
Molecular Formula C13H17N
CAS Number 14611-51-9
SMILES C[C@H](CC1=CC=CC=C1)N(C)CC#C
External Links
DRUGBANK DB01037
T3DB T3D2965
PubChem Compound 26757
PDR 133
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.7 - 2.7 - DRUGBANK
Melting Point 141.5 ℃ 141-142 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 0 % ~0 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1.1 ng/ml 1.1±0.4 ng/ml PO, oral; adults; The Pharmacological Basis of Therapeutics
C Max 15.0 ng/ml ~15 ng/ml PO, oral; Active metabolite; adults; The Pharmacological Basis of Therapeutics
T Max 0.70 h 0.7±0.4 h PO, oral; adults; The Pharmacological Basis of Therapeutics
T Max 1.0 h ~1 h PO, oral; Active metabolite; adults; The Pharmacological Basis of Therapeutics
Clearance 90.0 L/h/kg ~1500 ml/min/kg apparent clearance; metabolism of ugt; The Pharmacological Basis of Therapeutics
Clearance 9.6 L/h/kg 160.0 ml/min/kg apparent clearance; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 1.2 L/h/kg 20 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.9 L/kg 1.9 L/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.9 L/kg 1.9 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.6 h 1.2-2 h DRUGBANK
Half-life 1.9 h 1.9±1.0 h The Pharmacological Basis of Therapeutics
Half-life 21.0 h 21 h The Pharmacological Basis of Therapeutics
Half-life 18.0 h 18 h The Pharmacological Basis of Therapeutics
Half-life 1.3 h 1.3 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 63.0 mg/kg 63.0 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Toxicity LD50 63.0 mg/kg 63.0 mg/kg intravenous injection, IV; Rattus, Rat; T3DB
Eliminate Route 0 % ~0 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 99.5 % >99.5 % DRUGBANK
Protein Binding 94.0 % 94 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 0.0 0 Transdermal preparations Emsam selegiline PDR
Max dose for adults 10.0 mg/day 10 mg/day PO, oral Emsam selegiline PDR
Max dose for adults 2.5 mg/day 2.5 mg/day Tablet,PO，oral Emsam selegiline PDR
Max dose for adults 12.0 mg/day 12 mg/day Transdermal preparations Emsam selegiline PDR
Max dose for geriatric 10.0 mg/day 10 mg/day PO, oral Emsam selegiline PDR
Max dose for geriatric 2.5 mg/day 2.5 mg/day PO, oral Emsam selegiline PDR
Max dose for geriatric 12.0 mg/day 12 mg/day Transdermal preparations Emsam selegiline PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1