Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01036 ...
Drug Name Tolterodine
Molecular Weight 325.4876
Molecular Formula C22H31NO
CAS Number 124937-51-5
SMILES CC(C)N(CC[C@H](C1=CC=CC=C1)C1=C(O)C=CC(C)=C1)C(C)C
External Links
DRUGBANK DB01036
PubChem Compound 443879
PDR 476
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 5.6 - 5.6 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 26.0 % 26±18 % PO, oral; Male, men; adults; normal,healthy; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
Bioavailability 91.0 % 91±40 % PO, oral; Male, men; adults; normal,healthy; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
C Max 5.2 ng/ml 5.2±5.7 ng/ml PO, oral; Male, men; adults; normal,healthy; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
C Max 38.0 ng/ml 38±15 ng/ml PO, oral; Male, men; adults; normal,healthy; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
T Max 1.2 h 1.2±0.5 h PO, oral; Male, men; adults; normal,healthy; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
T Max 1.9 h 1.9±1.0 h PO, oral; Male, men; adults; normal,healthy; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
Clearance 0.58 L/h/kg 9.6±2.8 ml/min/kg extensive metabolizers, EM; normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Clearance 0.12 L/h/kg 2.0±0.3 ml/min/kg poor metabolizers, PM; normal,healthy; adults; Male, men; hepatopathy，LD ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.50 L/h/kg 8.4 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 113.0 L 113 ± 26.7 L DRUGBANK
Volume of Distribution 1.7 L/kg 1.7±0.4 L/kg extensive metabolizers, EM; normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.5 L/kg 1.5±0.4 L/kg poor metabolizers, PM; normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.5 L/kg 1.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.8 h 1.9-3.7 h DRUGBANK
Half-life 2.3 h 2.3±0.3 h extensive metabolizers, EM; normal,healthy; adults; Male, men; chronic liver disease ↑ ; The Pharmacological Basis of Therapeutics
Half-life 9.2 h 9.2±1.2 h poor metabolizers, PM; normal,healthy; adults; Male, men; chronic liver disease ↑ ; The Pharmacological Basis of Therapeutics
Half-life 2.4 h 2.4 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 77.0 % 77 % Urinary excretion; PO, oral; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 17.0 % 17 % Faeces excretion; PO, oral; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 0 % ~0 % Urinary excretion; adults; Male, men; normal,healthy; extensive metabolizers, EM; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 2.5 % <2.5 % Urinary excretion; adults; Male, men; normal,healthy; poor metabolizers, PM; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 96.3 % ~96.3 % DRUGBANK
Protein Binding 96.3 % 96.3 % adults; Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics
Protein Binding 64.0 % 64 % Active metabolite; adults; Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 4.0 mg/day 4 mg/day PO, oral Detrol tolterodine tartrate PDR
Max dose for elderly 4.0 mg/day 4 mg/day PO, oral Detrol tolterodine tartrate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1