Basic Information
| Drug ID | DDPD01032 |
|
| Drug Name | Probenecid | |
| Molecular Weight | 285.359 | |
| Molecular Formula | C13H19NO4S | |
| CAS Number | 57-66-9 | |
| SMILES | CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB01032 | |
| PubChem Compound | 4911 | |
| PDR | 1984 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.21 | - | 3.21 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 195.0 | ℃ | 195 | ℃ | PhysProp |
| Water Solubility | 27.1 | mg/L | 27.1 | mg/L | DRUGBANK |
| pKa | 3.4 | - | 3.4 | - | SANGSTER (1994) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.0150 | L/h/kg | 0.25 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.13 | L/kg | 0.13 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 9.0 | h | 6-12 | h | DRUGBANK | Half-life | 5.9 | h | 5.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 85.0 | % | 75-95 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.0 | 0 | Probenecid | probenecid | PDR | |||
| Max dose for infants | 0.0 | 0 | Probenecid | probenecid | PDR | |||
| Max dose for children | 2.0 | mg/day | 2 | g/day | PO, oral | Probenecid | probenecid | PDR |
| Max dose for children | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Probenecid | probenecid | PDR |
| Max dose for children | 1.2 | g/m2 | 1.2 | g/m2 | PO, oral | Probenecid | probenecid | PDR |
| Max dose for children | 2000.0 | mg/day | 2 | g/day | PO, oral | Probenecid | probenecid | PDR |
| Max dose for children | 0.0 | 0 | Probenecid | probenecid | PDR | |||
| Max dose for adolescents | 2000.0 | mg/day | 2 | g/day | PO, oral | Probenecid | probenecid | PDR |
| Max dose for adolescents | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Probenecid | probenecid | PDR |
| Max dose for adolescents | 1200.0 | mg/m2/dose | 1.2 | g/m2/dose | PO, oral | Probenecid | probenecid | PDR |
| Max dose for adolescents | 2000.0 | mg/day | 2 | g/day | PO, oral | Probenecid | probenecid | PDR |
| Max dose for adults | 2000.0 | mg/day | 2 | g/day | PO, oral | Probenecid | probenecid | PDR |
| Max dose for geriatric | 2000.0 | mg/day | 2 | g/day | PO, oral | Probenecid | probenecid | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1