Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01029 ...
Drug Name Irbesartan
Molecular Weight 428.5294
Molecular Formula C25H28N6O
CAS Number 138402-11-6
SMILES CCCCC1=NC2(CCCC2)C(=O)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NNN=N1
External Links
DRUGBANK DB01029
PubChem Compound 3749
PDR 2344
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.5 - 4.5 - http://www.chemspider.com/Chemical-Structure.3618.html
Boiling Point 648.6 ℃ 648.6 ℃ http://www.chemspider.com/Chemical-Structure.3618.html
Melting Point 180.5 ℃ 180-181 ℃ http://www.chemspider.com/Chemical-Structure.3618.html
Water Solubility 1000.0 mg/L <1 mg/ml http://www.chemspider.com/Chemical-Structure.3618.html

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 9700.0 ng.h/ml 9.7±3.0 ug.h/ml Oral single dose; DRUGBANK
AUC 20000.0 ng.h/ml 20.0±5.2 ug.h/ml Oral single dose; DRUGBANK
AUC 32600.0 ng.h/ml 32.6±11.9 ug.h/ml Oral single dose; DRUGBANK
AUC 44800.0 ng.h/ml 44.8±20.0 ug.h/ml Oral single dose; DRUGBANK
AUC 9300.0 ng.h/ml 9.3±3.0 ug.h/ml Oral multiple dose; DRUGBANK
AUC 19800.0 ng.h/ml 19.8±5.8 ug.h/ml Oral multiple dose; DRUGBANK
AUC 31900.0 ng.h/ml 31.9±9.7 ug.h/ml Oral multiple dose; DRUGBANK
AUC 34200.0 ng.h/ml 34.2±9.3 ug.h/ml Oral multiple dose; DRUGBANK
Bioavailability 70.0 % 60-80 % PO, oral; food; food → ; DRUGBANK
Bioavailability 70.0 % 60-80 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1900.0 ng/ml 1.9±0.4 ug/ml Oral single dose; DRUGBANK
C Max 2900.0 ng/ml 2.9±0.9 ug/ml Oral single dose; DRUGBANK
C Max 4900.0 ng/ml 4.9±1.2 ug/ml Oral single dose; DRUGBANK
C Max 5300.0 ng/ml 5.3±1.9 ug/ml Oral single dose; DRUGBANK
C Max 2040.0 ng/ml 2.04±0.4 ug/ml Oral multiple dose; DRUGBANK
C Max 3300.0 ng/ml 3.3±0.8 ug/ml Oral multiple dose; DRUGBANK
C Max 4400.0 ng/ml 4.4±0.7 ug/ml Oral multiple dose; DRUGBANK
C Max 5600.0 ng/ml 5.6±2.1 ug/ml Oral multiple dose; DRUGBANK
C Max 1300.0 ng/ml 1.3±0.4 mcg/ml Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.8 h 1.5-2 h PO, oral; food; food → ; DRUGBANK
T Max 1.5 h 1.5 h Oral single dose; DRUGBANK
T Max 1.5 h 1.5 h Oral single dose; DRUGBANK
T Max 1.5 h 1.5 h Oral single dose; DRUGBANK
T Max 1.5 h 1.5 h Oral single dose; DRUGBANK
T Max 1.5 h 1.5 h Oral multiple dose; DRUGBANK
T Max 2.0 h 2.0 h Oral multiple dose; DRUGBANK
T Max 1.5 h 1.5 h Oral multiple dose; DRUGBANK
T Max 1.8 h 1.8 h Oral multiple dose; DRUGBANK
T Max 1.2 h 1.2(0.7-2) h Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 10.0 L/h 157-176 ml/min Plasma clearance; DRUGBANK
Clearance 0.20 L/h 3.0-3.5 ml/min Renal clearance; DRUGBANK
Clearance 0.13 L/h/kg 2.12±0.54 ml/min/kg Elderly ↓ ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 0.14 L/h/kg 2.3 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 73.0 L 53-93 L DRUGBANK
Volume of Distribution 0.72 L/kg 0.72±0.20 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.94 L/kg 0.94 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 13.0 h 11-15 h elimination half-life; DRUGBANK
Half-life 13.0 h 13±6.2 h normal,healthy; Male, men; The Pharmacological Basis of Therapeutics
Half-life 14.0 h 14 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity TDLo 0.71 mg/kg/day 30.0 mg/kg/6W PO, oral; human, homo sapiens; DRUGBANK
Eliminate Route 20.0 % 20 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 80.0 % 80 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 2.0 % <2 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 2.2 % 2.2±0.9 % Urinary excretion; Male, men; normal,healthy; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 90.0 % 90 % plasma proteins; DRUGBANK
Protein Binding 90.0 % 90 % Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 0.27 mg/kg/day 0.27 mg/kg/day PO, oral Vasotec enalapril maleate PDR
Max dose for neonates 10.0 mcg/kg/dose 10 mcg/kg/dose intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for infants 0.58 mg/kg/day 0.58 mg/kg/day PO, oral Vasotec enalapril maleate PDR
Max dose for infants 0.94 mg/kg/day 0.94 mg/kg/day PO, oral Vasotec enalapril maleate PDR
Max dose for infants 0.01 mg/kg/dose 10 mcg/kg/dose intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for children 0.58 mg/kg/day 0.58 mg/kg/day PO, oral Vasotec enalapril maleate PDR
Max dose for children 40.0 mg/day 40 mg/day PO, oral Vasotec enalapril maleate PDR
Max dose for children 0.94 mg/kg/day 0.94 mg/kg/day PO, oral Vasotec enalapril maleate PDR
Max dose for children 0.01 mg/kg/dose 10 mcg/kg/dose intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for children 1.25 mg/dose 1.25 mg/dose intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for adolescents 40.0 mg/day 40 mg/day PO, oral Vasotec enalapril maleate PDR
Max dose for adolescents 0.01 mg/kg/dose 10 mcg/kg/dose intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for adolescents 1.25 mg/dose 1.25 mg/dose intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for adolescents 0.58 mg/kg/day 0.58 mg/kg/day PO, oral Vasotec enalapril maleate PDR
Max dose for adolescents 40.0 mg/day 40 mg/day PO, oral Vasotec enalapril maleate PDR
Max dose for adolescents 0.94 mg/kg/day 0.94 mg/kg/day PO, oral Vasotec enalapril maleate PDR
Max dose for adolescents 0.01 mg/kg/dose 10 mcg/kg/dose intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for adolescents 1.25 mg/dose 1.25 mg/dose intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for adults 40.0 mg/day 40 mg/day PO, oral Vasotec enalapril maleate PDR
Max dose for adults 20.0 mg/day 20 mg/day intravenous injection, IV Vasotec enalapril maleate PDR
Max dose for geriatric 40.0 mg/day 40 mg/day PO, oral Vasotec enalapril maleate PDR
Max dose for geriatric 20.0 mg/day 20 mg/day intravenous injection, IV Vasotec enalapril maleate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1