Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01023 ...
Drug Name Felodipine
Molecular Weight 384.254
Molecular Formula C18H19Cl2NO4
CAS Number 72509-76-3
SMILES CCOC(=O)C1=C(C)NC(C)=C(C1C1=C(Cl)C(Cl)=CC=C1)C(=O)OC
External Links
DRUGBANK DB01023
PubChem Compound 3333
PDR 1398
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -4.64 - -4.64 - ADME Research, USCD
Log P 3.86 - 3.86 - SANGSTER (1994)
Melting Point 145.0 ℃ 145 ℃ DRUGBANK
Water Solubility 19.7 mg/L 19.7 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % 100 % PO, oral; food; food → ; DRUGBANK
Bioavailability 15.0 % 15 % PO, oral; food; food → ; DRUGBANK
Bioavailability 15.0 % 15±8 % The Pharmacological Basis of Therapeutics
C Max 13.1 ng/ml 34±26 nM PO, oral; immediate release formulation; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 3.5 ng/ml 9.1±7.3 nM PO, oral; extended release formulation; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.90 h 0.9±0.4 h PO, oral; immediate release formulation; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 3.7 h 3.7±0.9 h PO, oral; extended release formulation; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 48.0 L/h 0.8 L/min normal,healthy; young; DRUGBANK
Clearance 0.72 L/h/kg 12±5 ml/min/kg hydrolysis; Elderly ↓ ;Hepatic cirrhosis, cirr ↓ ;congestive heart disease ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.66 L/h/kg 11 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 10.0 L/kg 10.0 L/kg DRUGBANK
Volume of Distribution 10.0 L/kg 10±3 L/kg Elderly → ;Hepatic cirrhosis, cirr ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 4.4 L/kg 4.4 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 24.5 h 17.5-31.5 h hypertension; patients; DRUGBANK
Half-life 27.5 h 19.1-35.9 h Elderly; hypertension; patients; DRUGBANK
Half-life 14.1 h 8.5-19.7 h normal,healthy; DRUGBANK
Half-life 14.0 h 14±4 h congestive heart disease ↑ ;Hepatic cirrhosis, cirr → ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 10.0 h 10 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 1050.0 mg/kg 1050.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 99.0 % 99 % DRUGBANK
Protein Binding 99.6 % 99.6±0.2 % Elderly → ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 0.6 mg/kg/day 0.6 mg/kg/day PO, oral Felodipine felodipine PDR
Max dose for children 20.0 mg/day 20 mg/day PO, oral Felodipine felodipine PDR
Max dose for adolescents 0.6 mg/kg/day 0.6 mg/kg/day PO, oral Felodipine felodipine PDR
Max dose for adolescents 20.0 mg/day 20 mg/day PO, oral Felodipine felodipine PDR
Max dose for adults 10.0 mg/day 10 mg/day PO, oral Felodipine felodipine PDR
Max dose for elderly 10.0 mg/day 10 mg/day PO, oral Felodipine felodipine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1